| Parameters |
Piceatannol |
Resveratrol |
| Nomenclature |
3,3′,4′,5-trans-trihydroxystilbene |
3,4′,5-trans-trihydroxystilbene |
| Spectrophotometric analysis in ethanol |
Absorbs maximally at 322 nm |
Absorbs maximally at 308 nm. |
| Content in grapes |
About 4-times lower than resveratrol |
about 4-times higher than piceatannol |
| Inhibitory activity |
Does not inhibit CYP2E1 (Cytochrome P450 2E1) |
Inhibits CYP2E1 (Cytochrome P450 2E1) |
| Scavenging activity |
Show stronger activity to scavenge free radicals. Higher rate constant of reaction with linoleate (LOO•)
Concentration of piceatannol required to scavenge O2•- is 1200 times lower than that of Resveratrol |
Lower rate constant of reaction with linoleate (LOO•) |
| Substrate of enzyme catechol-O-methyltransferase (COMT) |
Substrate of enzyme catechol-O-methyltransferase (COMT) due to presence of extra 3’-OH group |
Not a substrate of enzyme catechol-O-methyltransferase (COMT) |
Inhibition of MRP1-mediated transport of 2′,7′-bis-(carboxypropyl)-5(6)-carboxyfluorescein (BCPCF) from
human erythrocytes |
Show moderate activity |
Ineffective |
| Hormetic effect |
Piceatannol-induced hormetic response has been reported |
Not reported till now |
| TPA-induced NFkB DNA binding |
Inhibits NFkB DNAbinding to a greater extent |
inhibits NFkB DNAbinding to a lesser extent |
