Figure 3: Schematic illustration of different formats of small bispecific antibodies, containing only the variable domains.The parental monoclonal antibodies are represented above. (A) Bispecific diabody with the VH-VL configuration and illustration of the short linker. (B) Bispecific T-cell engager antibodies (BiTEs), with the two different antigen-binging sites binding to CD3 and to a tumor-related antigen.