| Determinants |
Favourable |
Unfavourable |
| White blood cell count |
<10 x 109/L |
>20 x 109/L |
| Age |
3-7years |
<1, > 10 years |
| Gender |
Female |
Male |
| Ethnicity |
White |
Black |
| Node, liver, spleen enlargement |
Absent |
Massive |
| Testicular enlargement |
Absent |
Present |
| CNS leukemia |
Absent |
Present |
| FAB morphologic features |
L1 |
L2 |
| Ploidy |
Hyperploidy |
Hypoploidy |
| Cytogenetic markers |
Trisomies 4, 10, and/or 17 |
t(9;22) |
| |
t(12;21) |
t(4;11) |
| Time to remission |
<14 days |
>28 days |
| Minimal residual disease |
< 10-4 |
>10-3 |
|
