No Initial Age at dx Phase Sokal’s risk Mutation at diagnosis Response P-loop Outside P-loop 1 PP 28 Chronic Low NM NM CHR within 3 months 2 N 24 Chronic Low NM NM CHR within 3 months 3 AL 38 Chronic High NM NM CHR within 3 months 4 JR 61 Chronic High NM NM CHR within 3 months 5 F 24 Chronic High NM NM CHR within 3 months 6 SR 45 Chronic Low NM NM CHR within 3 months 7 M 36 Chronic High NM n.1152 C→T(silent mutation) Drop out 8 KKK (†) 47 Chronic Intermediate NM V506S No response 9 UBW (†) 54 Chronic High NM N231Q No response 10 A (†) 45 Chronic High NM c.661_662insG and c.1555_1557insG No response 11 I 59 Accelerated Low NM NM CHR in 4 to 6 months 12 AP 20 Accelerated High NM NM CHR in 10 to 12 months 13 AH (†) 50 Accelerated High NM E509G No response 14 H (†) 41 Blast crisis High NM NM No response 15 M (†) 51 Chronic High NM NM No response 16 TS 56 Chronic Intermediate NM NM CHR within 3 months 17 S 32 Chronic High NM NM CHR in 7 to 9 months 18 ME 32 Chronic Intermediate NM NM CHR within 3 months 19 MFA (†) 39 Chronic Intermediate NM NM CHR within 3 months 20 ES 34 Accelerated High NM NM CHR within 3 months 21 PR 39 Accelerated High NM NM CHR in 4 to 6 months 22 S (†) 21 Blast crisis High NM NM No response 23 TF 26 Blast crisis High NM NM CHR within 3 months 24 MA 34 Chronic High NM NM CHR within 3 months 25 YNK 40 Chronic Intermediate NM NM Not determined 26 WG   Chronic Low NM NM CHR within 3 months 27 HY   Chronic High NM M351T Died of blastic crisis 28 Was   Chronic Intermediate NM NM CHR within 3 months 29 WF   Chronic Intermediate NM NM Died of blastic crisis 30 UK   Chronic High NM NM Died of blastic crisis 31 TF   Blast crisis High NM NM Not MMR 32 TA   Blast crisis High NM NM CHR within 3 months 33 Syaf   Chronic Intermediate NM NM CHR within 3 months 34 Sur   Chronic Low NM NM CHR within 3 months 35 Sol   Chronic High NM NM Died of blastic crisis 36 SA   Chronic High NM NM Died of blastic crisis 37 RP   Chronic Intermediate NM NM CHR within 3 months 38 RSu   Accelerated High NM NM CHR within 3 months 39 R So   Chronic Low NM NM CHR within 3 months 40 RY   Chronic High NM NM CHR within 3 months 41 PR   Accelerated High NM NM CHR within 3 months 42 NM   Accelated High NM NM No MMR, but still alive 43 NS   Chronic High NM NM CHR within 3 months 44 TS   Chronic Intermediate Y253H NM Died during 15 mo’s IM treatment *NM: no mutation

Table 5: Mutations profile of CML patients.