N = 41 % Age at diagnosis Median age 58   Range 35-77   Sex Male 29 71 Female 12 29 ISS I 16 39 II 12 29 III 13 32 Immunoglobulin isotype IgG 24 59 IgA 5 12 IgM 3 7 LC 9 22 Karyotype Normal 8 20 Aberrant 28 68 Not reported 5 12 Cytogenetic risk group (by FISH) High risk* 9 22 Standard risk 27 66

N: Number of Patients; ISS: International Staging System; LC: Light chain myeloma; FISH: Fluorescence In-Situ Hybridization. *High risk cytogenetics defined as t(4;14), t(14;16) and/or del17p

Table 1: Clinical data and disease characteristics of the patients.