All grades Grade III/IV N = 41 % N = 41 % Herpes zoster 2 5 2 5 Infections (bacterial) 8 20 3 7 Peripheral neuropathy 18 44 1 2 Neutropenia 8 20 2 5 Thrombocytopenia 6 15 3 7 Thromboembolic events 2 5 1 2 Nausea 1 2 0 0

Table 3a: Adverse events associated with VTD therapy.