OR 95% CI P-value TLS –(n=191) TLS +
(n=41)
Variables
4.18 1.98-8.83 <0.001 30(25.2%) 24(58.5%) Baseline WBC≥20000/µL
2.38 1.36-5.87 0.005 42(35.6%) 25(61%) Splenomegaly
2.54 1.2-5.37 0.013 28(23.5%) 18(43.9%) Hepatomegaly
4.45 1.56-12.67 0.003 8(7.2%) 9 (25.7%) Mediastinal mass
7.6 2.41-23.91 <0.001 5(4.2%) 10 (25%) Renal involvement
10.93 2.10-56.87 0.001 2(1.7%) 6 (16.25) CNS involvement
4.66 1.75-12.39 0.001 9(8%) 11(28.9%) T-cell immunophenotype
3.88 1.52-9.89 0.003 11(4.7%) 16(19.8%) Baseline LDH ≥2000 U/L
1.81 075-4.32 0.18 18(15.1%) 10(24.4%) Age ≥10 yr
1.55 0.76-3.17 0.23 71(59.7%) 20(48.8%) Male sex
Table 2A: The predictors of TLS in patients with ALL (Univariate analysis).