Symptoms of acute systemic reaction Circuit clotting AVF thrombus Platelet count (×109/L) at ASR Maximum fall (%) in platelet count Timing of platelet fall ( days) 1 Dyspnea, chills, fever +** - 53 85 14 2 Nausea, vomiting - + 25 88 12 3* Dyspnea, flushing, chills, fever, - - 16 90 13 4 Dyspnea, chest pain + - 28 94 7 5 Dyspnea, chest pain, hypotension, nausea, vomiting - + 84 72 13 6* Dyspnea, fever + - 57 67 8 7*** Dyspnea, chills, nausea + - 92 80 11 8 Dyspnea, chills, fever, chest pain, nausea + - 74 73 11 *diagnosed with pseudo-pulmonary embolism, ** unexpected closure of hollow fibers of dialyzer with fibrin-platelet aggregates in two consecutive sessions, ***heparin flushing on non-session day.

Table 5: Eight patients with HIT-induced acute systemic reaction from twenty-seven dialytic patients who experienced some acute systemic reaction.