Period , number of institutions, number of patients Median age at diagnosis of ITP (y) Median age at splenectomy (y)1 Median delay diagnosis - splenectomy (y)2 Median follow up (y) Global response at last follow- up4 Peri- operative bleeding(n) OPSI
El Hafy et al, 2004   Egypte 1980 – 1996 1 institution  
N = 112


NA3
     
9.5 (6 – 16)       0.8 (0.3 – 2.6)       9 (5 – 16)       45%
> 100 G/L    
NA       0 death 2 pneumococcal sepsis hospitalized (1 immunization, 2 prophylaxis)  
Aronis et al,2004Greece 1975 – 2002  1 institutionN = 33 NA 12 3.3 (0.6 – 14.5) 18.8 (6 – 25) 85%
  > 150 G/L
2 1 death, septic shock(no immunization, no prophylaxis)No sepsis
Donato et al,2006Italy 1981-2005   1 country, 7 institutionsN = 30 8 NA 2.5 (1 – 6) 4.9 (1 – 13) 73%
  > 150 G/L
NA 0 death  Sepsis not specified
Ramenghi etal, 2006Argentina NA - 2002  1 country, 11 institutionsN = 90 8 (1.3 – 17.8) 11.3 (2.4 – 22.4) 2.4 ( 0.5 – 19.4) 3.9 (0.4 – 15) 75%  
> 50 G/L
NA 1 death, sepsis(immunization and prophylaxis NA) 10 “infectious episodes”
Kühne et al,2007ICIS 1997 – 2006  25 countries, 57institutions N = 134 9.5 (1.1 – 18.7) 11.8 (2.7 – 20.7) 1.8 (0.1 – 10.8) 2 (0.1 – 4.5) 69%  
> 150 G/L
8 0 death  7 sepsis
Our study,2011France 2000 – 2009  1 country, 16 institutions  N = 78 9.6 (0.8 – 16.5) 12.4 (3.5 – 17.4) 2 (0.1 – 13.5) 3.4 (0.1 – 13.5) 84%
  > 100 G/L 
51% in CCR
2 0 death  No sepsis
1Number of children of less than 5 years old: our study: 3/78 (4%) 2Number of children splenectomized for newly-diagnosed or persistent ITP: Kühne: 41/134 (31%), our study: 16/78 (20%), 3NA : Not available. 4NB: response criteria in those studies were heterogeneous.
Table 2: Main informative collaborative studies of children who underwent splenectomy for ITP.