Figure 1a: LC-DAD chromatogram for the glyburide and its metabolites in (a) Human Liver microsomes (HLM) and (b) Mouse Liver microsomes (MLM); M1 to M5 represents monohydroxylated metabolites; M6 is ring loss metabolite; M7 is dihydroxylated metabolite; M8 & M9 are metabolite due to hydroxylation and dehydrogenation.