Parameters |
TLC method |
RP-HPLC method |
ALP |
BENZ |
ALP |
BENZ |
L.P Mixturesa |
98.71 ± 0.940 |
99.19 ± 0.938 |
98.68 ± 1.196 |
100.39 ± 1.285 |
Alloben® tabletsb
(B.No.100251) |
99.40 ± 1.447 |
98.66 ± 0.842 |
100.47 ± 0.954 |
98.46 ± 0.565 |
Standard additiona |
99.72 ± 0.569 |
98.97 ± 0.519 |
97.96 ± 1.107 |
98.93 ± 0.543 |
Degree of freedomc
F-test |
2.454
(2.787)* |
1.954
(2.450)* |
0.496
(2.210)* |
1.241
(2.357)* |
Degree of freedomc
Student’st- test |
4.214
(4.818)* |
3.247
(4.224)* |
2.097
(4.245)* |
3.846
(3.971)* |
|
aAverage of 3 determinations |
bAverage of 6 determinations |
cFigures between parenthesis represent the corresponding tabulated values of t and F at P = 0.05. |
cHPLC method using: phosphate buffer (pH=4.0)-acetonitrile- methanol (50: 30: 20, v/v/v) as a mobile phase and 250 nm as the detection wavelength. |
Table 1: Determination of the studied drugs in the laboratory prepared mixtures (L.P.) and pharmaceutical preparation by the proposed methods and statistical comparison
with the reported RP-HPLC methods. |