1024 Monoclonal antibody
  AN/IS Area ratio in samples spiked after extraction AN/IS Area ratio in neat solvent
Parameters VS Low 450.0 ng/mL VS High 8500.0 ng/mL VS Low 450.0 ng/mL VS High 8500.0 ng/mL
Mean area ratio 0.658 9.66 0.501 9.39
Normalized matrix effect 1.3 1.0    
n 6 6 6 6
992 Monoclonal antibody
  AN/IS Area ratio in samples spiked after extraction AN/IS Area ratio in neat solvent
Parameters VS Low 450.0 ng/mL VS High 8500.0 ng/mL VS Low 450.0 ng/mL VS High 8500.0 ng/mL
Mean area ratio 0.334 5.13 0.275 5.92
Normalized matrix effect 1.2 0.9    
n 6 6 6 6
Table 9: Matrix effect of the LC-MS/MS analysis of 1024 mAb and 992 mAb in monkey serum.