Mixture |
T90 (days) |
FOS |
DEX |
OND |
Adj |
Exp |
Adj |
Exp |
Adj |
Exp |
O0 |
O1 |
O0 |
O1 |
O0 |
O1 |
1 |
- |
- |
15 |
- |
- |
15 |
27 |
27 |
15 |
2 |
- |
- |
15 |
- |
- |
15 |
53 |
55 |
15 |
3 |
28 |
29 |
15 |
45 |
70 |
15 |
15 |
15 |
15 |
4 |
12 |
12 |
15 |
- |
- |
15 |
- |
- |
15 |
5 |
- |
- |
15 |
- |
- |
15 |
- |
- |
15 |
6 |
- |
- |
15 |
- |
- |
15 |
- |
- |
15 |
7 |
- |
- |
15 |
- |
- |
15 |
- |
- |
15 |
8 |
- |
- |
15 |
- |
- |
15 |
22 |
22 |
15 |
9 |
- |
- |
15 |
- |
- |
15 |
- |
- |
15 |
10 |
19 |
20 |
15 |
51 |
53 |
15 |
- |
- |
15 |
11 |
- |
- |
15 |
- |
- |
15 |
- |
- |
15 |
12 |
- |
- |
15 |
17 |
17 |
15 |
- |
- |
15 |
|
FOS: Fosaprepitant DEX: Dexamethasone OND: Ondansetron
Adj: value obtained from kinetic adjust
Exp: experimental time at which %RC was ≥ 90%
O0: zero-order kinetic adjust
O1: first-order kinetic adjust
%RC: Percentage of remaining drug concentration |
Table 6: T90 values for mixtures containing FDO assayed. |