Mixture T90 (days)
FOS DEX OND
Adj Exp Adj Exp Adj Exp
O0 O1 O0 O1 O0 O1
1 - - 15 - - 15 27 27 15
2 - - 15 - - 15 53 55 15
3 28 29 15 45 70 15 15 15 15
4 12 12 15 - - 15 - - 15
5 - - 15 - - 15 - - 15
6 - - 15 - - 15 - - 15
7 - - 15 - - 15 - - 15
8 - - 15 - - 15 22 22 15
9 - - 15 - - 15 - - 15
10 19 20 15 51 53 15 - - 15
11 - - 15 - - 15 - - 15
12 - - 15 17 17 15 - - 15
FOS: Fosaprepitant DEX: Dexamethasone OND: Ondansetron
Adj: value obtained from kinetic adjust
Exp: experimental time at which %RC was ≥ 90%
O0: zero-order kinetic adjust
O1: first-order kinetic adjust
%RC: Percentage of remaining drug concentration
Table 6: T90 values for mixtures containing FDO assayed.