Table 2a Parameter Pre-PMA (N=36) PMA (N=29) P value AA 0.70±0.11 0.75±0.04 0.04 ASDE 0.27±0.04 0.29±0.02 0.004 LFAP 8.01±1.89 9.09±1.35 0.01 HFAP 1.57±0.16 1.68±0.20 0.01 EEE 84.0±7.83 93.8±10.58 <10-3 Table 2b Parameter Pre-T3 (N=48) T3 (N=38) P value AA 0.74±0.07 0.22±0.14 <10-3 ASDE 0.27±0.03 0.17±0.04 <10-3 LFAP 8.06±1.45 3.37±1.16 <10-3 HFAP 1.54±0.05 1.85±0.38 <10-3 EEE 82.7±4.34 95.3±20.33 <10-3 Table 2c Parameter Pre-hypo 37°C (N=38) Mild hypo 27°C(N=38) P value AA 0.61±0.06 0.56±0.11 0.01 ASDE 0.25±0.02 0.25±0.03 0.43 LFAP 7.04±0.73 6.88±1.34 0.22 HFAP 1.82±0.06 1.88±0.06 <10-3 EEE 98.0±4.7 100.5±4.7 0.005

Table 2: Average and standard deviation (SD) of fluctuation parameters: AA, ASDE, Low Frequency Average Power (LFAP, f ≤ 0.1 Hz), High Frequency Average Power (HFAP, f>0.5 Hz), and Energy Expenditure Evaluation (EEE) values in normal U-937 cells and cells 24 hours post-incubation with PMA (Table 2a), normal U-937 cells and cells 30 minutes post-stimulation with T3 (Table 2b) and cells pre- and post- mild hypothermic stress (Table 2c). N-Number of cells in each group.