Extracting solvent (%) Process efficiency (%) ion-suppression
9-cRA 4-oxo-9-cRA 9-cRA 4-oxo-9-cRA
Ethyl acetate 55.4 28.5 28.2 42.5
Methyl tert-butyl ether 42.7 22.5 42.8 37.8
Diethyl ether 25.7 14.5 25.8 30.5
Diethyl ether:ethyl acetate (50:50, v/v) 52.4 46.5 32.2 35.6
Dichloromethane:n-hexane (50:50, v/v) 45.5 25.8 28.6 38.5
Dichloromethane:n-hexane:IPA (75:20:5, v/v) 62.7 35.8 14.5 51.4
Ethyl acetate:n-hexane (50:50, v/v) 65.2 42.4 21.0 33.5
Ethyl acetate:n-hexane:IPA (30:65:5, v/v/v) 95.0 95.5 0.4 1.9
Table 2: Effect of extracting solvent on process efficiency and ion suppression.