| Analyte name |
Formulation |
PK Parameters |
| Tmax (h) |
Cmax (ng/mL) |
AUC0→t (h.ng/mL) |
AUC0→∞ (h.ng/mL) |
t1/2 (h) |
| 9-cRA |
R1 |
2.81 ± 1.25 |
210.20 ± 172.59 |
456.33 ± 281.43 |
522.88 ± 311.64 |
3.89±3.13 |
| R2 |
3.14 ± 1.26 |
203.02 ± 99.06 |
471.71 ± 192.27 |
494.98 ± 201.35 |
3.64±1.94 |
| T |
3.04 ± 1.08 |
205.42 ± 121.70 |
451.85 ± 246.12 |
498.98 ± 239.16 |
3.35±3.07 |
| 4-oxo-9-cRA |
R1 |
2.96 ± 1.22 |
24.29 ± 22.67 |
38.55 ± 34.68 |
54.56 ± 29.94 |
0.59±0.31 |
| R2 |
3.24 ± 1.24 |
25.48 ± 17.60 |
40.56 ± 20.94 |
54.55 ± 23.48 |
0.61±0.27 |
| T |
3.08 ± 1.10 |
29.01 ± 24.21 |
47.00 ± 22.54 |
77.26 ± 32.52 |
0.49±0.19 |
| R1 and R2 are the reference product; T is test product |
|
