Vehicle Enalapril 20 mg/kg/day (1) Vehicle Enalapril 20 mg/kg/day (1) Vehicle Enalapril 20 mg/kg/day (1)
MAP (mmHg) 52 ± 2 40 ± 2 ** 55 ± 2 40 ± 1 *** 49 ± 1 38 ± 2 ***
SAP (mmHg) 68 ± 1 61 ± 3 * 72 ± 2 61 ± 2 *** 63 ± 1 56 ± 2 **
DAP (mmHg) 44 ± 2 30 ± 2 *** 48 ± 2 30 ± 2 *** 42 ± 1 30 ± 2 ***
HR (bpm) 180 ± 9 157 ± 8 NS 197 ± 7 180 ± 4 * 193 ± 5 186 ± 9 NS
CO (ml/min) 9.9 ± 0.8 8.2 ± 0.6 NS 5.7 ± 0.7 6.2 ± 0.5 NS 9.8 ± 0.4 10.0 ±0.5 NS
SV (ml) 0.056 ± 0.005 0.054 ± 0.004 NS 0.029 ± 0.003 0.034 ± 0.002 NS 0.051 ± 0.003 0.056 ± 0.004 NS
TPRes (mmHg/min/ml) 5.6 ± 0.6 5.0 ± 0.3 NS 10.8 ± 1.6 6.7 ± 0.4 * 5.1 ± 0.3 3.9 ± 0.3 **
MAP : Mean Aortic Blood Pressure ; SAP : Systolic Aortic Blood Pressure ; DAP : Diastolic Aortic Blood Pressure ; HR : Heart Rate ; CO : Cardiac Output ; SV : Stroke Volume ; TPRes : Total Peripheral Resistance.
Data are means s.e.m.
(1): One-way ANOVA (with group as factor): NS = Not Significant ; * = p < 0.05 ; ** = p < 0.01 ; *** = p < 0.001.
Table 1: Effects of enalapril (20 mg/kg/day) on mean, systolic and diastolic aortic blood pressure, heart rate, cardiac output, stroke volume and total peripheral resistances in cardiomyopathic hamsters (n = 8 to 12 per group).