Vehicle

Enalapril

20 mg/kg/day

(1)

Vehicle

Enalapril

20 mg/kg/day

(1)

Vehicle

Enalapril

20 mg/kg/day

(1)

MAP (mmHg)

52 ± 2

40 ± 2

**

55 ± 2

40 ± 1

***

49 ± 1

38 ± 2

***

SAP (mmHg)

68 ± 1

61 ± 3

*

72 ± 2

61 ± 2

***

63 ± 1

56 ± 2

**

DAP (mmHg)

44 ± 2

30 ± 2

***

48 ± 2

30 ± 2

***

42 ± 1

30 ± 2

***

HR (bpm)

180 ± 9

157 ± 8

NS

197 ± 7

180 ± 4

*

193 ± 5

186 ± 9

NS

CO (ml/min)

9.9 ± 0.8

8.2 ± 0.6

NS

5.7 ± 0.7

6.2 ± 0.5

NS

9.8 ± 0.4

10.0 ±0.5

NS

SV (ml)

0.056 ± 0.005

0.054 ± 0.004

NS

0.029 ± 0.003

0.034 ± 0.002

NS

0.051 ± 0.003

0.056 ± 0.004

NS

TPRes (mmHg/min/ml)

5.6 ± 0.6

5.0 ± 0.3

NS

10.8 ± 1.6

6.7 ± 0.4

*

5.1 ± 0.3

3.9 ± 0.3

**


MAP : Mean Aortic Blood Pressure ; SAP : Systolic Aortic Blood Pressure ; DAP : Diastolic Aortic Blood Pressure ; HR : Heart Rate ; CO : Cardiac Output ; SV : Stroke Volume ; TPRes : Total Peripheral Resistance.
Data are means s.e.m.
(1): One-way ANOVA (with group as factor): NS = Not Significant ; * = p < 0.05 ; ** = p < 0.01 ; *** = p < 0.001.
Table 1: Effects of enalapril (20 mg/kg/day) on mean, systolic and diastolic aortic blood pressure, heart rate, cardiac output, stroke volume and total peripheral resistances in cardiomyopathic hamsters (n = 8 to 12 per group).