Early treatment from 60 to 200 days of age Late treatment from 120 to 200 days of age Prolonged treatment from 120 to 250 days of age   Vehicle Enalapril 20 mg/kg/day (1) Vehicle Enalapril 20 mg/kg/day (1) Vehicle Enalapril 20 mg/kg/day (1) BW (g) 110 ± 7 110 ± 3 NS 120 ± 3 111 ± 4 NS 122 ± 3 101 ± 3 *** AW/BW (mg/g) 0.35 ± 0.04 0.28 ± 0.03 NS 0.27 ± 0.02 0.21 ± 0.01 * 0.44 ± 0.03 0.29 ± 0.01 *** LVW/BW (mg/g) 2.54 ± 0.16 2.34 ± 0.03 NS 2.47 ± 0.07 2.37 ± 0.09 NS 2.55 ± 0.04 2.53 ± 0.03 NS RVW/BW (mg/g) 0.67 ± 0.06 0.61 ± 0.03 NS 0.53 ± 0.02 0.56 ± 0.04 NS 0.68 ± 0.03 0.64 ± 0.01 NS LiW/BW (mg/g) 31.05 ± 0.67 30.26 ± 0.74 NS 39.57 ± 1.81 36.68 ± 1.48 NS 28.69 ± 0.45 30.32 ± 0.63 * LuW/BW (mg/g) 5.82 ± 0.43 6.18 ± 0.40 NS 4.42 ± 0.08 4.48 ± 0.12 NS 5.57 ± 0.31 5.20 ± 0.17 NS BW : Body Weight ; AW : Atria Weight ; LVW : Left Ventricle Weight ; RVW : Right Ventricle Weight ; LiW : Liver Weight ; LuW : Lungs Weight. Data are means ± s.e.m. (1): One-way ANOVA (with group as factor): NS = Not Significant ; * = p < 0.05; *** = p < 0.001.

Table 2: Effects of enalapril (20 mg/kg) on body weight and atria, left ventricle, right ventricle, liver and lungs normalized weights in the cardiomyopathic hamsters (n = 10 to 12 per group).