Figure 3: Coronary flow, coronary resistance and cumulated coronary catecholamines (CA) overflow after ischemia/reperfusion with and without hyperosmotic perfusion. Hyperosmotic NaCl perfusion enhanced coronary flow (a, b) and reduced coronary vascular resistance (c, d) after ischemia/reperfusion in a dose-dependent way, in both normotensive Wistar-Kyoto rats (WKY) and stroke-prone spontaneously hypertensive rats (SHRSP). Coronary norepinephrine overflow was reduced in hyperosmotic perfused WKY and SHRSP hearts (e, f) in a pattern similar with the reduction in coronary resistance, with the best effect being in 350 mOsm/L group. CA, catecholamines. n=7-10. *P<0.05, **P<0.01 versus respective controls.