Variables Younger <70 years (n=115) Elderly ≥70 years (n=111) p value
Age, years 59.7 ± 0.88 77.1 ± 0.4 <0.0001
Male, % 71.3 % 63.8 % 0.31
Smoking status, % 17.1 % 3.0 % 0.0009
BMI, Kg/m2 29.6 ± 0.59 27.9 ± 0.5 0.02
Waist circumference, cm 104.2 ± 1.59 101.4 ± 1.55 0.21
Hypertension, % 56.4 % 68.9 % 0.04
Diabetes, % 23.3 % 34.3 % 0.09
Glycemia, mmol/L 5.87 ± 0.13 5.80 ± 0.15 0.88
Metabolic syndrome, % 28.1 % 23.0 % 0.43
CAD, % 66.4 % 50.0 % 0.02
Lipids
LDL-cholesterol, mmol/L 2.5 ± 0.08 2.1 ± 0.08 0.002
HDL-cholesterol, mmol/L 1.3 ± 0.03 1.3 ± 0.04 0.85
Triglycerides, mmol/L 1.58 ± 0.08 1.32 ± 0.59 0.01
Statines, % 97.1 % 96.1 % 1
ACE inhibitors/ARBs, % 40.7 % 47.5 % 0.33
Bicuspid valve, % 49.5 % 7.7 % <0.0001
Creatinine, mmol/L 86.9 ± 1.7 97.1 ± 2.4 0.0007
CRP, mg/L 2.45 ± 0.36 2.52 ± 0.31 0.89
Fetuin A, g/L 0.46 ± 0.02 0.36 ± 0.02 0.0006
Preoperative peak transvalvular gradient, mmHg 71 ± 3 71 ± 2 0.5
Preoperative aortic valve area, cm2 0.78 ± 0.2 0.73 ± 0.18 0.1
Annualized peak transvalvular gradient, mmHg/year 7.99 ± 0.9 9.10 ± 0.8 0.38
Annualized aortic valve area, cm2/year -0.12 ± 0.1 -0.12 ± 0.1 0.1
Aortic valve calcium content, mg/ g ww tissue 56.9 ± 3.86 58.7 ± 3.26 0.72

Legend: BMI: body mass index; CAD: coronary artery disease; LDL: low-density lipoprotein; HDL: high-density lipoprotein;
ACE: angiotensin-converting enzyme; ARB: angiotensin receptor blockers;
CRP: C-reactive protein. Values are mean ± SEM
Table 1: Baseline characteristics of patients in younger and elderly group.