Vehicle (n=13)

LPS (n=16)

LPS+4F (n=13)

baseline

24hr

% change

baseline

24hr

% change

baseline

24hr

% change

BW (g)

316 ± 10

315 ± 11

-1 ± 1

303 ± 8

279 ± 9

-8 ± 1 *

302 ± 10

282 ± 12

-7 ± 1 *

IVSd (mm)

1.51 ± 0.06

1.51 ± 0.04

1 ± 4

1.50 ± 0.04

1.79 ± 0.06

20 ± 3 *

1.54 ± 0.06

1.62 ± 0.06

7 ± 6 #

PWd (mm)

1.44 ±  0.07

1.45 ± 0.07

1 ± 4

1.41 ±  0.05

1.81 ± 0.09

30 ± 8 *

1.54 ±  0.05

1.64 ± 0.04

8 ± 4 #

LVEDd (mm)

8.10 ±  0.16

8.07 ± 0.14

1 ± 1

7.95 ± 0.12

6.95 ± 0.15

-13 ± 1 *

7.86 ± 0.19

7.43 ± 0.24

-5 ± 2 *,#

EDV (mL)

0.56 ± 0.03

0.56 ± 0.03

-1 ± 4

0.53 ± 0.02

0.36 ± 0.02

-32 ± 3 *

0.52 ± 0.04

0.45 ± 0.04

-13 ± 7 #

IVSs (mm)

2.48 ± 0.11

2.43 ± 0.08

-1 ± 4

2.53 ± 0.06

2.66 ± 0.06

6 ± 2

2.55 ± 0.06

2.43 ± 0.07

-4 ± 5

PWs (mm)

2.44 ±  0.06

2.55 ± 0.09

5 ± 3

2.36 ±  0.09

2.68 ± 0.10

16 ± 6

2.44 ±  0.08

2.61 ± 0.07

8 ± 5

LVESd (mm)

5.06 ±  0.17

4.95 ± 0.12

-1 ± 3

4.97 ± 0.15

4.38 ± 0.09

-11 ± 2

4.89 ± 0.20

4.65 ± 0.27

-4 ± 6

ESV (mL)

0.14 ± 0.01

0.13 ± 0.01

-6 ± 8

0.13 ± 0.01

0.09 ± 0.01

-27 ± 6

0.13 ± 0.02

0.12 ± 0.02

-11 ± 14

FS

0.38 ± 0.02

0.39 ± 0.01

5 ± 6

0.38 ± 0.01

0.37 ± 0.01

-1 ± 4

0.38 ± 0.01

0.38 ± 0.02

-1 ± 6

EF (%)

75 ± 2

77 ± 1

3 ± 3

75 ± 2

74 ± 1

-1 ± 3

76 ± 1

75 ± 3

-1 ± 4

Table 1: Effects of LPS administration and 4F treatment on cardiac dimensional changes. Data are the mean ± SEM and are presented as absolute values and as percent changes within each group over the 24 hr study period. *(P < 0.05) denotes a significant difference compared to sham-operated rats. # (P < 0.05) denotes a significant difference compared to LPS-treated rats.