Electrolytes plasma concentrations (mmol/L) course in rats before (A) and after (B) furosemide, with or without BPC 157 medication |
- Course in rats before furosemide
|
Drug protocol:
Furosemide
challenge |
- Course in rats after furosemide
|
Route |
Drug protocol:
saline,
BPC 157,
nothing |
Electrolytes plasma concentrations (mmol/L) |
Electrolytes plasma concentrations (mmol/L) |
Drug protocol:
nothing, saline,
BPC 157 |
Electrolytes plasma concentrations (mmol/L) |
K |
Na |
Cl |
K |
Na |
Cl |
K |
Na |
Cl |
Regimen |
i.p. |
saline+ |
4.4±
0.7 |
134.0±1.1 |
80.2±4.1 |
+Furosemide |
2.70±0.24* |
135.25±2.1 |
81.25±6.06 |
/ |
2.70±
0.19* |
134.00±2.5 |
79.9±
4.7 |
P
R
O
P
H
Y
L
A
C
T
I
C
T
H
E
R
A
P
E
U
T
I
C |
BPC157 10μg/kg+ |
4.3±
0.6 |
133.8±1.3 |
77.9±5.3 |
+Furosemide |
2.87±0.23* |
134.5±
0.87 |
79.75±2.95 |
/ |
2.74±
0.15* |
134±
0.71 |
81.9±
5.0 |
BPC157
10ng/kg+ |
4.2±
0.3 |
133.7±0.8 |
79.2±2.7 |
+Furosemide |
2.87±0.26* |
132.25±2.28 |
76.5±
4.77 |
/ |
2.78±
0.19* |
132.7±1.09 |
76.2±
2.6 |
i.g. |
saline+ |
4.7±
0.6 |
136.7±1.1 |
80.2±4.1 |
+Furosemide |
2.91±0.24* |
130.55±2.1 |
81.25±6.06 |
/ |
2.80±
0.39* |
138.0±0.95 |
79.4±
3.7 |
BPC157 10μg/kg+ |
4.1±
0.8 |
137.8±1.5 |
78.9±7.3 |
+Furosemide |
2.77±0.38* |
132.7±0.67 |
77.15±3.97 |
/ |
2.64±
0.15* |
134.9±0.71 |
81.0±
5.0 |
BPC157
10ng/kg+ |
4.6±
0.3 |
132.9±0.7 |
78.8±2.7 |
+Furosemide |
2.67±0.18* |
134.55±3.28 |
79.9±
5.77 |
/ |
2.88±
0.32* |
138.7±2.1 |
77.2±
5.6 |
i.p. |
/ |
4.3±
0.5 |
134.0±1.6 |
78.8±3.9 |
Furosemide+ |
2.72±0.18* |
135.0±
1.58 |
79.8±
4.15 |
+ saline |
2.8±
0.1* |
135.0±1.92 |
80.2±
3.3 |
/ |
4.1±
0.8 |
133.9±1.8 |
80.5±2.9 |
Furosemide+ |
2.86±0.23* |
138.9±
1.26 |
81.0±
3.63 |
+ BPC157 10μg/kg |
2.74±
0.15* |
134.8±0.95 |
81.5±
4.9 |
/ |
4.3±
0.4 |
134.4±1.8 |
79.4±5.1 |
Furosemide+ |
2.84±0.27* |
132.9±
2.07 |
76.6±
4.77 |
+ BPC157 10ng/kg |
2.76±
0.13* |
138.5±2.45 |
76.8±
1.9 |
i.g. |
/ |
4.8±
0.6 |
134.9±2.7 |
80.8±4.9 |
Furosemide+ |
2.72±0.18* |
138.9±
3.55 |
80.8±
5.15 |
+ saline |
2.6±
0.1* |
135.0±1.92 |
78.2±
5.3 |
/ |
4.3±
0.8 |
135.7±3.8 |
79.5±3.9 |
Furosemide+ |
2.86±0.23* |
135.4±
4.26 |
81.9±
3.63 |
+ BPC157 10μg/kg |
2.54±
0.35* |
134.8±0.71 |
81.9±
6.0 |
/ |
4.3±
0.4 |
136.4±2.8 |
77.4±5.8 |
Furosemide+ |
2.84±0.27* |
134.9±
3.05 |
78.6±
5.77 |
+ BPC157 10ng/kg |
2.46±
0.33* |
134.9±2.45 |
79.8±
4.9 |
|
Medication at 15 min before furosemide |
Presentation before furosemide challenge |
Furosemide (100 mg/kg i.p.)
challenge |
Presentation at 90 minute
after furosemide challenge |
Medication at 90 min after furosemide |
Presentation at 150 min after furosemide challenge |
Presentation at 60 min
after BPC 157/saline medication
(therapeutic regimen) |