Electrolytes plasma concentrations (mmol/L) course in rats before (A) and after (B) furosemide, with or without BPC 157 medication
  1. Course in rats before furosemide
 Drug protocol: Furosemide challenge
  1. Course in rats after furosemide
Route Drug protocol: saline, BPC 157, nothing Electrolytes plasma concentrations (mmol/L) Electrolytes plasma concentrations (mmol/L) Drug protocol: nothing, saline, BPC 157 Electrolytes plasma concentrations (mmol/L)
K Na Cl K Na Cl K Na Cl Regimen
i.p. saline+ 4.4± 0.7 134.0±1.1 80.2±4.1 +Furosemide 2.70±0.24* 135.25±2.1 81.25±6.06   / 2.70± 0.19* 134.00±2.5 79.9± 4.7 P
R
O
P
H
Y
L
A
C
T
I
C
T
H
E
R
A
P
E
U
T
I
C
BPC157 10μg/kg+ 4.3± 0.6 133.8±1.3 77.9±5.3 +Furosemide 2.87±0.23* 134.5± 0.87 79.75±2.95   / 2.74± 0.15* 134± 0.71 81.9± 5.0
BPC157 10ng/kg+ 4.2± 0.3 133.7±0.8 79.2±2.7 +Furosemide 2.87±0.26* 132.25±2.28 76.5± 4.77   / 2.78± 0.19* 132.7±1.09 76.2± 2.6
i.g. saline+ 4.7± 0.6 136.7±1.1 80.2±4.1 +Furosemide 2.91±0.24* 130.55±2.1 81.25±6.06   / 2.80± 0.39* 138.0±0.95 79.4± 3.7
BPC157 10μg/kg+ 4.1± 0.8 137.8±1.5 78.9±7.3 +Furosemide 2.77±0.38* 132.7±0.67 77.15±3.97   / 2.64± 0.15* 134.9±0.71 81.0± 5.0
BPC157 10ng/kg+ 4.6± 0.3 132.9±0.7 78.8±2.7 +Furosemide 2.67±0.18* 134.55±3.28 79.9± 5.77   / 2.88± 0.32* 138.7±2.1 77.2± 5.6
i.p.   / 4.3± 0.5 134.0±1.6 78.8±3.9 Furosemide+ 2.72±0.18* 135.0± 1.58 79.8± 4.15 + saline 2.8± 0.1* 135.0±1.92 80.2± 3.3
  / 4.1± 0.8 133.9±1.8 80.5±2.9 Furosemide+ 2.86±0.23* 138.9± 1.26 81.0± 3.63 + BPC157 10μg/kg  2.74± 0.15* 134.8±0.95 81.5± 4.9
  / 4.3± 0.4 134.4±1.8 79.4±5.1 Furosemide+ 2.84±0.27* 132.9± 2.07 76.6± 4.77 + BPC157 10ng/kg  2.76± 0.13* 138.5±2.45 76.8± 1.9
i.g.   / 4.8± 0.6 134.9±2.7 80.8±4.9 Furosemide+ 2.72±0.18* 138.9± 3.55 80.8± 5.15 + saline 2.6± 0.1* 135.0±1.92 78.2± 5.3
  / 4.3± 0.8 135.7±3.8 79.5±3.9 Furosemide+ 2.86±0.23* 135.4± 4.26 81.9± 3.63 + BPC157 10μg/kg  2.54± 0.35* 134.8±0.71 81.9± 6.0
/ 4.3± 0.4 136.4±2.8 77.4±5.8 Furosemide+ 2.84±0.27* 134.9± 3.05 78.6± 5.77 + BPC157 10ng/kg  2.46± 0.33* 134.9±2.45 79.8± 4.9
  Medication at 15 min before  furosemide Presentation before furosemide challenge Furosemide (100 mg/kg i.p.) challenge Presentation at 90 minute after furosemide challenge Medication at 90 min after  furosemide Presentation at  150 min after furosemide challenge
Presentation at  60 min after BPC 157/saline medication (therapeutic regimen)
Table 1A: Electrolytes plasma concentrations (mmol/L), means ±SEM. BPC 157 administered intraperitoneally or intragastrically was given prophylactically before furosemide (100 mg/kg intraperitoneally) or alternatively, as a therapy, after furosemide, when hypokalemia- third-degree AV block and ventricular tachycardia were already established. * P<0.05, at least vs. initial presentation (italic) without furosemide.