Medication at 15 min before furosemide Cumulative amount of urine in a given time interval (ml)
Time after furosemide (post-furosemide time) (min)
5 15 30 45 60 75 90
Time after medication application (post-therapy time) (min)
20 30 45 60 75 90 105
CONTROL (SALINE 5ml/kg)¥ 0 0 1.1±0.9 3.1±1.4 5.1±1.5 6.1±1.7 7.6±1.8
BPC 157¥ 0 0 0* 0.9±0.8* 2.8±2.1* 5.9±2.2 7.6±1.9
L-NAME¥ 0.2±0.1 0.3±0.1 0.5±0.1 0.8±0.3* 1.1±0.7* 2.1±0.6* 3.2±1.7*
L-NAME + BPC 157¥ 0 0 0.4±0.8 1.7±0.4* 2.5±0.9* 3.7±0.8* 5.8±1.2*
L-arginine¥ 0 0 0* 1.1±0.7* 3.1±1.4* 6.1±1.9 7.7±1.5
L-arginine + BPC 157¥ 0 0 0* 1.2±0.9* 3.3±1.3* 5.9±1.1 7.5±1.4
L-NAME + L-arginine¥ 0 0.2±0.1 0.9±*0.2 1.7±1.2* 2.2±1.3* 3.6±1.1* 4.6±1.8*
L-NAME + L-arginine + BPC 157¥ 0 0 0* 1.2±0.9* 3.3±1.3* 5.9±1.1 7.2±1.2
Table 2B: Effects of BPC 157 (10 μg/kg i.p.), L-NAME (5 mg/kg i.p.) and L-arginine (100 mg/kg i.p.) on furosemide (100 mg/kg i.p.)-diuresis (mL). Values are mean ± SEM. ¥ - Two-way ANOVA with repeated measure on one factor (P<0.05) difference between measurements depends on group membership. *P<0.05 significantly different from control values.