Table 5B

Rhythm	RR interval duration (msec) after furosemide and before medication (per 5 min.)	Medication at 90 min after furosemide	Time after furosemide (post-furosemide time) (min)
			95	100	110	120	130	140	150
			Time after medication application (post-therapy time) (min)
			5	10	20	30	40	50	60
sinus rhythm	193.9±3.1	CONTROL (saline 5ml/kg i.p.) ¥	191.3±2.1	195±1.7	196.2±1.4	196.4±2.4	197.9±1.4	198.4±2.1	199.9±1.5
ventricular tachycardia	272.6±3.6		285.3±3.4	273.9±4.1	288.1±3.7	289.3±2.7	277.9±3.2	283.5±3.9	281.8±4.1
third-degree AV block	107±2.7		101.2±2.5	99.8±3.1	104.6±2.5	101.5±4.1	97.3±2.8	96.3±3.5	92.7±5.6
sinus rhythm	194.4±2.9	BPC 10μg/kg i.p. ¥	155.5±1.4†	160±2.5 †	157±2.1 †	166±1.7 †	165±0.8 †	162±0.9 †	161.2±1.4†
ventricular tachycardia	269.1±2.7		263.3±2.1	-	-	-	-	-	-
third-degree AV block	98.2.1±3.2		97.2±4.1	-	-	-	-	-	-
sinus rhythm	194.3±2.8	BPC 10ng/kg i.p. ¥	153.4±1.6†	162±3.6 †	164.1±2.7†	161.1±2.3†	162.1±2.3†	161.1±1.9†	161.2±2.2†
ventricular tachycardia	272.3±3.1	BPC 10ng/kg i.p. ¥	273.8± 2.6	-	-	-	-	-	-
third-degree AV block	98.6±2.1		99.1±2.6	-	-	-	-	-	-
sinus rhythm	195.7±2.6	CONTROL (saline 5ml/kg i.g.) ¥	194.7±2.4	195.1±1.2	195.5±1.8	196.1±1.9	196.5±2.5	197.1±1.7	198.1±2.1
ventricular tachycardia	295.2±2.9		294±3.7	287±5.1	269.2±3.1	286.3±3.4	299.1±2.1	285.7±4.1	279.9±2.9
third-degree AV block	101.7±2.4		104.2±2.5	99.4±2.1	96.3±3.6	100.2±2.2	97.8±3.6	94.3±5.1	92.2±3.9
sinus rhythm	196.1±2.1	BPC 10μg/kg i.g. ¥	195.7±2.2	169.1±1.9†	169.4±2.2†	169.6±2.3†	167.9±1.7†	167.7±1.6†	167.4±1.9 †
ventricular tachycardia	289.2±1.9		285.4±2.1	266.7±2.1	-	-	-	-	-
third-degree AV block	97.4±2.6		99.7±3.6	104.3±1.8	-	-	-	-	-
sinus rhythm	195.9±2.3	BPC 10ng/kg i.g. ¥	194.1±1.5	170.3±1.7†	171.1±2.3†	170.8±2.8†	170.1±1.4†	170.0±1.1†	169.4±1.8 †
ventricular tachycardia	289.3±2.5		294.5±4.1	288.1±2.6	-	-	-	-	-
third-degree AV block	98.4±2.1		101.6±3.1	99.4±2.7	-	-	-	-	-

Table 5B: Effects of hypokalemia on RR interval duration (msec) during sinus rhythm, ventricular tachicardia, third-degree AV block. BPC 157 (intraperitoneally or intragastrically) as a therapy, after furosemide (100 mg/kg intraperitoneally), when hypokalemia- third-degree AV block and ventricular tachycardia were already established. Values are mean ± SEM. ¥ - Two-way ANOVA with repeated measure on one factor (P<0.05) difference between measurements depends on group membership. †P<0.05 significantly different from control values.