The ECG rats were monitored throughout the 60 min, after reaching a severe hypokalemia at 90min after administration of furosemide. Medication given 15 min before furosemide. REGIMEN STUDY GROUPS Number of premature ventricular beats (per 60 min), Mean±S.D. Duration of ventricular tachycardia (min), Mean±S.D. Duration of third-degree AV block (min), Mean±S.D. Absolute termination of arrhythmias (min), Mean±S.D. Time till fatal outcome (min), Mean±S.D. Mortality rate (surviving/dead rats) PROPHYLACTIC CONTROL (SALINE 5ml/kg) 103.4±4.2 19.8±2.7 8.9±1.8 0 57.3±4.2 0/10 BPC 157 2.1±0.1 † 0 † 0 † - Not determined 10/0 † L-NAME 156±5.6 † 11.9±3.6 † 25.7±4.1 † 0 31.2±1.5 † 0/10 L-NAME + BPC 157 128.2±3.7 † 7.9±2.1 † 3.1±0.8 † 9.2±2.3 † Not determined 10/0 † L-arginine 100.8±2.9 17.9±1.5 7.5±1.5 26.3±3.1 † Not determined 10/0 † L-arginine + BPC 157 42.7±5.8 † 4.5±1.4 † 1.2±0.4 † 5.3±3.7 † Not determined 10/0 † L-NAME + L-arginine 108.3±5.1 18.5±2.3 9.4±2.1 0 59.6±3.4 0/10 L-NAME + L-arginine + BPC 157 52.9±6.1 † 0 † 0 † - Not determined 10/0 †

Table 7A: Development of furosemide-induced hypokalemic arrhythmias after application of pentadecapeptide BPC 157 (10 μg/kg i.p.), L-NAME (5 mg/kg i.p.), inhibitor of NO-synthase, and L-arginine (100 mg/kg i.p.), substrate of NO-synthase and NO-precursor – PROPHYLACTIC REGIMEN (medication given 15 min. before furosemide). +P≤0.05 at least vs. control.