The ECG rats were monitored throughout the 60 min after application of the medicaments. Medication given 90 min. after furosemide
REGIMEN STUDY GROUPS Number of premature
ventricular beats),
Mean±S.D.
Duration of ventricular
tachycardia (min),
Mean±S.D.
Duration of third-degree AV block (min),
Mean±S.D.
Absolute termination of arrhythmias (min.),
Mean±S.D.
Time till fatal outcome (min.), Mean±S.D. Mortality rate (surviving/
/dead rats)
THERAPEUTIC BASELINE
before
medication
(per 5min)
5–60 min. after
medication
BASELINE
before
medication
(per 5 min)
5–60 min after
Medication
BASELINE
before
medication
(per 5 min.)
5–60 min after
medication
CONTROL
(SALINE 5ml/kg)
11.7±3.1 104.1±3.6*¥ 0.7±0.3 18.3±2.1*¥ 0.8±0.4 6.8±1.5*¥ Not determined 55.6±3.8 0/10
BPC 157 10.2±2.8 4.4±2.1†*¥ 0.8±0.1 0 †*¥ 0.6±0.2 0 †*¥ 4.9±0.1 † Not determined 10/0 †
L-NAME 11.1±1.9 179.4±3.1†*¥ 0.6±0.1 29.2±2.2†*¥ 0.6±0.2 13.4±3.4†*¥ Not determined 25.4±3.6 † 0/10
L-NAME + BPC 157 12.6±2.4 52.6±1.8†*¥ 0.8±0.1 0.4±0.2†*¥ 0.7±0.3 0.4±0.6 †¥ 9.8±1.2 † Not determined 10/0 †
L-arginine 11.2±1.8 99.4±3.1*¥ 0.6±0.4 16.9±1.8*¥ 0.6±0.2 5.1±2.1 *¥ 26.3±3.1 † Not determined 10/0 †
L-arginine + BPC 157 11.5±2.1 47.9±2.1†*¥ 0.7±0.1 5.6±1.8†*¥ 0.7±0.4 1.1±0.7 †¥ 5.3±3.7 † Not determined 10/0 †
L-NAME + Larginine 11.6±2.2 113.2±3.7*¥ 0.6±0.3 20.2±1.9*¥ 0.8±0.1 10.7±2.9 *¥ Not determined 49.7±3.1 0/10
L-NAME + Larginine + BPC 157 11.7±2.1 58.8±4.2†*¥ 0.8±0.2 8.9±3.1†*¥ 0.7±0.3 3.5±1.4†*¥ 10.2±1.9 Not determined 10/0 †
Table 7B: The effect of pentadecapeptide BPC 157 (10 μg/kg i.p.), L-NAME (5 mg/kg i.p.), inhibitor of NO-synthase, and L-arginine (100 mg/kg i.p.), substrate of NOsynthase
on the established furosemide-induced hypokalemic arrhythmias in the rat – THERAPEUTIC REGIMEN (Medication given 90 min. after furosemide). ¥ - Two-way
ANOVA with repeated measure on one factor (P<0.05) difference between measurements depends on group membership. + P≤0.05 at least vs. control. * P≤0.05 at least
vs. baseline.