Table 7B

The ECG rats were monitored throughout the 60 min after application of the medicaments. Medication given 90 min. after furosemide
REGIMEN	STUDY GROUPS	Number of premature ventricular beats), Mean±S.D.		Duration of ventricular tachycardia (min), Mean±S.D.		Duration of third-degree AV block(min), Mean±S.D.		Absolute termination of arrhythmias (min.), Mean±S.D.	Time till fatal outcome (min.), Mean±S.D.	Mortality rate (surviving/ /dead rats)
THERAPEUTIC	STUDY GROUPS	BASELINE before medication (per 5min)	5–60 min. after medication	BASELINE before medication (per 5 min)	5–60 min after Medication	BASELINE before medication (per 5 min.)	5–60 min after medication	Absolute termination of arrhythmias (min.), Mean±S.D.	Time till fatal outcome (min.), Mean±S.D.	Mortality rate (surviving/ /dead rats)
	CONTROL (SALINE 5ml/kg)	11.7±3.1	104.1±3.6*¥	0.7±0.3	18.3±2.1*¥	0.8±0.4	6.8±1.5*¥	Not determined	55.6±3.8	0/10
	BPC 157	10.2±2.8	4.4±2.1†*¥	0.8±0.1	0 †*¥	0.6±0.2	0 †*¥	4.9±0.1 †	Not determined	10/0 †
	L-NAME	11.1±1.9	179.4±3.1†*¥	0.6±0.1	29.2±2.2†*¥	0.6±0.2	13.4±3.4†*¥	Not determined	25.4±3.6 †	0/10
	L-NAME + BPC 157	12.6±2.4	52.6±1.8†*¥	0.8±0.1	0.4±0.2†*¥	0.7±0.3	0.4±0.6 †¥	9.8±1.2 †	Not determined	10/0 †
	L-arginine	11.2±1.8	99.4±3.1*¥	0.6±0.4	16.9±1.8*¥	0.6±0.2	5.1±2.1 *¥	26.3±3.1 †	Not determined	10/0 †
	L-arginine + BPC 157	11.5±2.1	47.9±2.1†*¥	0.7±0.1	5.6±1.8†*¥	0.7±0.4	1.1±0.7 †¥	5.3±3.7 †	Not determined	10/0 †
	L-NAME + Larginine	11.6±2.2	113.2±3.7*¥	0.6±0.3	20.2±1.9*¥	0.8±0.1	10.7±2.9 *¥	Not determined	49.7±3.1	0/10
	L-NAME + Larginine + BPC 157	11.7±2.1	58.8±4.2†*¥	0.8±0.2	8.9±3.1†*¥	0.7±0.3	3.5±1.4†*¥	10.2±1.9	Not determined	10/0 †

Table 7B: The effect of pentadecapeptide BPC 157 (10 μg/kg i.p.), L-NAME (5 mg/kg i.p.), inhibitor of NO-synthase, and L-arginine (100 mg/kg i.p.), substrate of NOsynthase on the established furosemide-induced hypokalemic arrhythmias in the rat – THERAPEUTIC REGIMEN (Medication given 90 min. after furosemide). ¥ - Two-way ANOVA with repeated measure on one factor (P<0.05) difference between measurements depends on group membership. + P≤0.05 at least vs. control. * P≤0.05 at least vs. baseline.