Figure 6: Activity levels of enzymes implicated in myocardial energy metabolism. HADH (hydroxyacyl-Coenzyme A dehydrogenase), HK (hexokinase) and CS (citrate synthase) enzymatic activities were measured in LV homogenates from at least 10 animals in each group as described in the Materials and Methods. Results are reported as mean ± SEM (n=10- 15/gr). Two-way ANOVA analyses are displayed below each panel. D X T: disease and metformin treatment interaction.