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Figure 7: Evaluation by real-time quantitative RT-PCR of the LV mRNA levels of genes related to cardiac metabolism. Glucose transporters 1 and 4 (Glut1 and Glut4), fatty acid transporter (FAT/CD36), carnityl palmitoyl transferases (Cpt 1b and 2), PDK4 (pyruvate dehydrogenase kinase 4) PDH1a (pyruvate dehydrogenase 1alpha), MCAD (medium-chain acyl- CoA dehydrogenase),UCP3 (uncoupling protein 3), DGK ζ (diacylglycerol kinase ζ), Ant1 (adenine nucleotide transferase 1), PPAR α (peroxisome proliferator-activated receptor α) and PGC1 α (peroxisome proliferatoractivated receptor gamma coactivator-1 α). Results are reported in arbitrary units as mean ± SEM (n = 10/group). Untreated sham (sham-operated animals; SC) group mRNA levels were normalized to 1 and are represented by the black lane.*: p<0.05 vs. ARC group. |