Group

 TNF-α(pg/ml) hsCRP(mg/l)
I Normal group Zero time 0.60 ± 0.09 3.0 ± 0.0
6 weeks 1.08 ± 0.11 3.0 ± 0.0
12 weeks 1.05 ± 0.06 3.0 ± 0.0
II Induced untreated group Zero time 0.77 ± 0.10 3.0 ± 0.0
6 weeks 4.70 ± 0.54* 43 ± 1.8*
12 weeks 7.05 ± 0.44† 57 ± 3.0†
III vildagliptin treated group Zero time 0.85 ± 0.05 3.0 ± 0.0
6 weeks 4.60 ± 0.15* 41 ± 1.8*
12 weeks 2.70 ± 0.17† 19 ± 1.0†
* P < 0.05(means at 6 weeks versus means at zero time)
† P < 0.05(means at 12 weeks versus means at 6 weeks
Table 3: Effect of cholesterol enriched diet, vildagliptin 50mg/kg/day on serum inflammatory marker (TNF-α level in pg/ml and hsCRP in mg/l) the data expressed as mean ± SEM.