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Figure 1: Lack of TIMP3 increases susceptibility to AAA in the absence of metabolic syndrome. A) representative images of mouse aorta showing that 4 weeks of Ang II infusion (1.5 mg/Kg/day) resulted in AAA formation in TIMP3-/- but not in WT mice. (Modified from [48]). B) TIMP3-/--Ang II mice exhibited 18% mortality due to aortic rupture in the suprarenal region where aneurysm was detected. C) Different morphologies of AAA in TIMP3-/--Ang II mice. D) Schematic of molecular events leading to AAA in the absence of TIMP3. |