Mouse strain Aneurysm Model Phenotype Ref.
MMP2-/- CaCl2, abdominal Protection against AAA [46]
MMP3-/-/ApoE-/- Cholesterol rich diet Reduced thoracic and abdominal aneurysm formation (sustained atherosclerotic plaque). [58]
MMP8-/- Elastase, abdominal No change in AAA size [59]
MMP9-/- CaCl2, thoracic CaCl2, abdominal Elastase, abdominal Attenuated TAA Protection against AAA Protection against AAA [56]
MMP12-/- CaCl2, abdominal Elastase, abdominal Ang II + anti-TGFb Attenuated AAA No change in AAA size Protection against AAA [60]
MMP13-/- Elastase, abdominal Reduced AAA aortic dilation [97]
Cathepsin K-/- Cathepsin K-/-/ApoE-/- Elastase, abdominal Ang II + high fat diet Reduced AAA dilation Unchanged AAA [64]
Cystatin C-/-/ApoE-/- Ang II + high fat diet Exacerbated AAA dilation [66]
MCP4-/- (mast cell protein-4, Chymase) Elastase, abdominal Reduced AAA dilation [68]
Plg-/- CaCl2, abdominal Protected against AAA [70]
TIMP1-/- CaCl2, Thoracic Exacerbated TAA. [74]
TIMP1-/-/ApoE-/- Cholesterol-rich diet Enhanced thoracic and abdominal aneurysm formation, (reduced atherosclerotic plaque) [73]
TIMP2-/- CaCl2, abdominal Attenuated AAA [75]
TIMP3-/- Ang II infusion Suprarenal AAA formation [48]
TIMP3-/-/MMP2-/- Ang II infusion Exacerbated AAA dilation [48]
Table 1: Summary of abdominal aortic aneurysm formation in protease or TIMP-deficient mouse models. AAA = abdominal aortic aneurysm; ApoE = apolipoprotein E; CaCl2=calcium chloride; MCP-4 = mast cell protein-4; MMP = matrix metalloproteinase; plg = plasminogen; TAA = thoracic aortic aneurysm; TIMP = tissue inhibitor of matrix metalloproteinase.