Mouse strain |
Aneurysm Model |
Phenotype |
Ref. |
MMP2-/- |
CaCl2, abdominal |
Protection against AAA |
[46] |
MMP3-/-/ApoE-/- |
Cholesterol rich diet |
Reduced thoracic and abdominal aneurysm formation (sustained atherosclerotic plaque). |
[58] |
MMP8-/- |
Elastase, abdominal |
No change in AAA size |
[59] |
MMP9-/- |
CaCl2, thoracic
CaCl2, abdominal
Elastase, abdominal |
Attenuated TAA
Protection against AAA
Protection against AAA |
[56]
[46]
[45] |
MMP12-/- |
CaCl2, abdominal
Elastase, abdominal
Ang II + anti-TGFb |
Attenuated AAA
No change in AAA size
Protection against AAA |
[60]
[45]
[96] |
MMP13-/- |
Elastase, abdominal |
Reduced AAA aortic dilation |
[97] |
Cathepsin K-/-
Cathepsin K-/-/ApoE-/- |
Elastase, abdominal
Ang II + high fat diet |
Reduced AAA dilation
Unchanged AAA |
[64]
[49] |
Cystatin C-/-/ApoE-/- |
Ang II + high fat diet |
Exacerbated AAA dilation |
[66] |
MCP4-/- (mast cell protein-4, Chymase) |
Elastase, abdominal |
Reduced AAA dilation |
[68] |
Plg-/- |
CaCl2, abdominal |
Protected against AAA |
[70] |
TIMP1-/- |
CaCl2, Thoracic |
Exacerbated TAA. |
[74] |
TIMP1-/-/ApoE-/- |
Cholesterol-rich diet |
Enhanced thoracic and abdominal aneurysm formation, (reduced atherosclerotic plaque) |
[73] |
TIMP2-/- |
CaCl2, abdominal |
Attenuated AAA |
[75] |
TIMP3-/- |
Ang II infusion |
Suprarenal AAA formation |
[48] |
TIMP3-/-/MMP2-/- |
Ang II infusion |
Exacerbated AAA dilation |
[48] |
|