Table 1

Mouse strain	Aneurysm Model	Phenotype	Ref.
MMP2^-/-	CaCl₂, abdominal	Protection against AAA	[46]
MMP3^-/-/ApoE^-/-	Cholesterol rich diet	Reduced thoracic and abdominal aneurysm formation (sustained atherosclerotic plaque).	[58]
MMP8^-/-	Elastase, abdominal	No change in AAA size	[59]
MMP9^-/-	CaCl₂, thoracic CaCl₂, abdominal Elastase, abdominal	Attenuated TAA Protection against AAA Protection against AAA	[56] [46] [45]
MMP12^-/-	CaCl₂, abdominal Elastase, abdominal Ang II + anti-TGFb	Attenuated AAA No change in AAA size Protection against AAA	[60] [45] [96]
MMP13^-/-	Elastase, abdominal	Reduced AAA aortic dilation	[97]
Cathepsin K^-/- Cathepsin K^-/-/ApoE^-/-	Elastase, abdominal Ang II + high fat diet	Reduced AAA dilation Unchanged AAA	[64] [49]
Cystatin C^-/-/ApoE^-/-	Ang II + high fat diet	Exacerbated AAA dilation	[66]
MCP4^-/- (mast cell protein-4, Chymase)	Elastase, abdominal	Reduced AAA dilation	[68]
Plg^-/-	CaCl₂, abdominal	Protected against AAA	[70]
TIMP1^-/-	CaCl₂, Thoracic	Exacerbated TAA.	[74]
TIMP1^-/-/ApoE^-/-	Cholesterol-rich diet	Enhanced thoracic and abdominal aneurysm formation, (reduced atherosclerotic plaque)	[73]
TIMP2^-/-	CaCl₂, abdominal	Attenuated AAA	[75]
TIMP3^-/-	Ang II infusion	Suprarenal AAA formation	[48]
TIMP3^-/-/MMP2^-/-	Ang II infusion	Exacerbated AAA dilation	[48]

Table 1: Summary of abdominal aortic aneurysm formation in protease or TIMP-deficient mouse models. AAA = abdominal aortic aneurysm; ApoE = apolipoprotein E; CaCl₂=calcium chloride; MCP-4 = mast cell protein-4; MMP = matrix metalloproteinase; plg = plasminogen; TAA = thoracic aortic aneurysm; TIMP = tissue inhibitor of matrix metalloproteinase.