Gender   Depression   Anxiety   CHF     Men Women P No Yes P No Yes P No Yes P MacNew domains n=612 n=161   n=648 n=125   n=597 n=179   n=670 n=103   Emotional function 5.6 (±0.9) 5.3 (±0.9) 0.0002 5.8 (±0.7) 4.4 (±0.9) <0.0001 5.9 (±0.7) 4.5 (±0.9) <0.0001 5.6 (±0.9) 5.4 (±1.0) 0.03 Physical limitation 5.5 (±1.1) 5.0 (±1.0) <0.0001 5.6 (±0.9) 4.2 (±1.0) <0.0001 5.6 (±0.9) 4.5 (±1.1) <0.0001 5.4 (±1.1) 5.1 (±1.1) 0.003 Social function 5.8 (±1.1) 5.5 (±1.0) 0.01 6.0 (±0.9) 4.5 (±1.1) <0.0001 6.0 (±0.9) 4.8 (±1.1) <0.0001 5.8 (±1.0) 5.5 (±1.1) 0.01 Global 5.6 (±0.9) 5.2 (±0.9) <0.0001 5.7 (±0.7) 4.3 (±0.9) <0.0001 5.8 (±0.7) 4.6 (±0.9) <0.0001 5.5 (±0.9) 5.3 (±1.0) 0.008

Table 2: Discriminant validity of MacNew global score and sub-scales by gender, depression, anxiety and CHF status, Mean (± SD).