Figure 1: Representative histological findings of evaluation of myocardial tissue after infarction (MI) in rats treated with M-2 (hematoxylin and eozine – stained). (A) Control specimens of the sham-operated heart, (B) Control 0.4% DMSO water solution at 28th day after MI, (C) Control 0.4% DMSO water solution at 35th day after MI, (D) M-2 from 11 to 28 day, (E) M-2 from 21 to 35 day, (F) M-2 from 6 to 35 day (scanned with 20x objective, bar represents 50 μm).
A. Compact structure without any inflammatory infiltrations.
B. Prominent features of cardiomyopathy were seen as cardiomyocytes thinning, stretching, disperse inflammatory cells and interstitial fibrosis.
C. Progressive cardiomyopathy with fibrosis and cardiomyocytes thinning and stretching, inflammatory cells were absent.
D. Cardiomyopathic signs with focal fibrosis and disperse inflammatory cells.
E. Progressive dilation of cardiomyocytes, without progressive fibrosis and inflammation.
F. The signs of cardiomyopathy (i.e. focal fibrosis and cardiomyocytes thinning and stretching) were replaced by cardiomyocytes hypertrophy with slight inflammatory infiltration. Similar changes were visible in group receiving M-2 from 11th to 35th day after MI.