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Figure 2: Effects of intravenous CoQ10 or saline injected at minute 60 or minute 180 after coronary artery occlusion vs. sham operation. Twenty-one days after ligation, slices were obtained and stained with triphenyltetrazolium chloride. Panels A: In the 60-min groups, CoQ10 intravenous injection is seen to limit LV dilatation and aneurism formation; scars are localized to within the ischemic LV wall. Panels B: In the saline-treated infarct animals, scar ompletely replaces myocardium within the LAD supply region. LAD: Left anterior descending coronary artery; LV: Left ventricle. |