Figure 1: Different vasculoprotective roles of the three NOS isoforms in a mouse carotid artery ligation model. Studies with each NOS isoform-/- mice demonstrated that eNOS inhibits neointimal formation, that iNOS attenuates constrictive vascular remodeling, and that nNOS suppresses both neointimal formation and constrictive vascular remodeling. Thus, individual NOS isoforms have different vasculoprotective actions against vascular lesion formation in mice in vivo inhibition [7].