A= Placebo, B= 600 μg, C=1200 μg, D=1600 μg, E=3200 μg.

Figure 1: Gross pathology after 24 hours of intracoronary collagenase injection. No effects were evident in placebo-treated (A) and lower dose collagenase (B). At higher doses, collagenase treated hearts had evidence of haemorrhages on the surface of the heart (C-E). Black arrow in panels indicate the haemorrhages.