Method (PW DTI vs TVI) Sites (Septal vs. lateral vs. posterior vs. anterior) Interaction (Method x Site)   Method mean difference (95 % CI) p p p Systolic         MA 30.6 (27.2 to 33.9) <0.001 <0.001 <0.001 AA 26.0 (22.7 to 29.2) <0.001 0.83 0.14 Early diastolic         MA 35.7 (32.7 to 38.6) <0.001 <0.001 <0.001 AA 20.2 (16.5 to 23.9) <0.001 <0.001 0.36 Late diastolic         MA 27.0 (23.2 to 30.7) <0.001 <0.001 0.022 AA 21.1 (17.0 to 25.1) <0.001 <0.001 0.81

Table 3: Comparison between PW DTI and TVI methods at MA and AA annuli for systolic, early and late diastolic velocities measured at different sites and assigned by two-way within factor ANOVA’s. MA: Mitral Annulus; AA: Aortic Annulus; PW DTI: Pulsed Wave Tissue Doppler Imaging; TVI: Colour Coded Tissue Doppler Imaging, CI: Confidence Interval (n=24) (Velocities in mm/s).