Liver-to-Spleen Ratio  
No. (%) or mean (±SD) ≥1 <1 p-value
N 3342 696 <0.001
Age 63 (11) 61 (10) 0.456
Male 1485 (44%) 320 (46%) <0.001
Race  
White 1271 (38%) 231 (33%) 0.016
Chinese 319 (10%) 79 (11%) 0.146
African-American 1058 (32%) 135 (19%) <0.001
Hispanic 694 (21%) 251 (36%) <0.001
Education  
<High School 592 (18%) 173 (25%) <0.001
HS + non-college level 1588 (48%) 327 (47%) 0.799
College or more 1148 (35%) 193 (28%) 0.001
Smoking 0.097
Never 1720 (52%) 389 (56%) 0.032
Former 1230 (37%) 230 (33%) 0.061
Current 379 (11%) 74 (11%) 0.592
Body Mass Index (kg/m2) 28.1 (5.2) 31.1 (5.4) <0.001
Diabetes 387 (12%) 157 (23%) <0.001
Hypertension 1529 (46%) 370 (53%) <0.001
SBP 127 (22) 130 (21) 0.001
DBP 70 (10) 73 (10) <0.001
HTN Meds 1274 (38%) 309 (44%) 0.002
LDL 118 (31) 116 (31) 0.162
HDL 52 (15) 45 (12) <0.001
Triglycerides* 105 [75, 152] 154 [107, 209] <0.001
Lipid lowering meds 540 (16%) 122 (18%) 0.379
Coagulation Markers  
CRP (mg/L)* 1.79 [0.81, 1.87] 2.94 [1.37, 6.28] <0.001
IL-6 (pg/mL)* 1.23 [0.78, 1.87] 1.52 [1.02, 2.37] <0.001
Waist circumference 97.4 (13.7) 105.7 (13.4) <0.001
Glucose 95.7 (28.5) 108.5 (39.2) <0.001
Table 1: Baseline characteristics among MESA participants with and without NAFLD (LSR<1)