Biomarker Unadjusted (95% CI) Adjusted* β (95% CI) LSR (per unit decrease)   CRP (per doubling) 0.023 (0.028, 0.018) 0.015 (0.009, 0.020) CRP ≥ 2.00 0.063 (0.046, 0.079) 0.037 (0.020, 0.054) IL-6 (per doubling) 0.027 (0.018, 0.036) 0.014 (0.004, 0.023) Liver attenuation (per unit decrease)   CRP (per doubling) 1.47 (1.26, 1.68) 0.81 (0.58, 1.03) CRP ≥ 2.00 3.85 (3.15, 4.55) 1.92 (1.20, 2.63) IL-6 (per doubling) 2.13 (1.76, 2.50) 1.08 (0.69, 1.47)

Table 2a: Association of CRP & IL-6 with NAFLD defined by continuous liver-to-spleen ratio and liver attenuation