Biomarker Unadjusted Odds Ratio (95% CI) Adjusted* Odds Ratio (95% CI) LSR<1   CRP (per doubling) 1.28 (1.22, 1.35) 1.15 (1.08, 1.23) CRP ≥ 2.00 1.96 (1.65, 2.32) 1.41 (1.16, 1.73) IL-6 (per doubling) 1.42 (1.30, 1.55) 1.18 (1.05, 1.31) Liver attenuation<40HU   CRP (per doubling) 1.44 (1.33, 1.57) 1.31 (1.18, 1.45) CRP ≥ 2.00 3.11 (2.32, 4.18) 2.27 (1.62, 3.16) IL-6 (per doubling) 1.60 (1.40, 1.83) 1.33 (1.13, 1.58)

Table 3a: Association of CRP & IL-6 with NAFLD defined by dichotomous liver-to-spleen ratio and liver attenuation <40 HU