| |
Improvement or no change in diastolic function (n=67) |
Worsening of diastolic function
(n=14) |
P value |
| Baseline Echocardiographic parameters |
|
|
|
| LVEDd/height, mm/m (n=80) |
27±3 |
28±3 |
0.24 |
| LVESd/height, mm/m (n=79) |
18±2 |
18±2 |
0.57 |
| LV mass index, g/m2 (n=76) |
45±9 |
38±10 |
0.020 |
| Ejection fraction, % |
59.7±4.0 |
60.4±5.0 |
0.54 |
| LA volume index, ml/m2 (n=78) |
22.9±5.3 |
22.1±5.2 |
0.61 |
| E, cm/s |
72±17 |
79±19 |
0.21 |
| A, cm/s |
70±20 |
80±19 |
0.095 |
| E/A |
1.2±1.1 |
1.0±0.3 |
0.49 |
| Deceleration time, ms |
209±34 |
216±38 |
0.52 |
| e’ lateral, cm/s |
11±4 |
11±3 |
0.30 |
| E/e’ |
6.6±1.9 |
8.0±2.9 |
0.022 |
| Systolic PAP (n=36) |
28±5 |
33±9 |
0.093 |
| Global longitudinal strain, % (n=76) |
-20±2 |
-19±3 |
0.35 |
| TAPSE (n=59) |
21±4 |
22±4 |
0.57 |
| Right ventricular S’ (n=70) |
13±2 |
13±2 |
0.88 |
| Follow-up Echocardiographic parameters |
|
|
|
| LVEDd/height, mm/m (n=78) |
28±3 |
27±2 |
0.49 |
| LVESd/height, mm/m (n=78) |
18±2 |
18±1 |
0.32 |
| LV mass index, g/m2 (n=76) |
46±8 |
41±8 |
0.04 |
| Ejection fraction, % |
59.0±4.0 |
59.5±3.8 |
0.67 |
| LA volume index, ml/m2 (n=78) |
23±6 |
25±6 |
0.40 |
| E, cm/s |
75±18 |
82±22 |
0.20 |
| A, cm/s |
74±18 |
89±27 |
0.015 |
| E/A |
1.01±0.3 |
0.96±0.29 |
0.28 |
| Deceleration time, ms |
197±35 |
233±56 |
0.04 |
| e’ lateral, cm/s |
12±3 |
9±1 |
0.001 |
| E/e’ |
6.9±2.1 |
9.5±3.6 |
0.001 |
| Systolic PAP (n=43) |
28±6 |
29±7 |
0.86 |
| Global longitudinal strain, % (n=76) |
-19.9±1.9 |
-18.8±2.0 |
0.16 |
| TAPSE (n=71) |
22±4 |
21±4 |
0.73 |
| Right ventricular S’ (n=71) |
14±2 |
13±2 |
0.34 |
| Ejection fraction drop ≥10% |
2(3.0%) |
1(7.1%) |
0.45 |
| Global longitudinal strain drop ≥-2% |
2(3.0%) |
1(7.1%) |
0.45 |
| Change in parameters: follow-baseline (Paired t-test P value) |
|
|
|
| Change in global longitudinal strain |
-0.15%±2.7% (p=0.82) |
+0.53%±0.16%(p=0.61) |
|
| Change in ejection fraction |
+0.69%±3.9% (p=0.16) |
-0.93%±5.2% (p=0.52) |
|
| Change in E/e’ |
-0.32±2.1(p=0.22) |
+1.47±1.9 (p=0.014) |
|
| Change in e’ |
-0.076±2.3(p=0.79) |
-1.6±2.2 (p=0.015) |
|
