Improvement or no change in diastolic function (n=67) Worsening of diastolic function
(n=14)
P value
Baseline Echocardiographic parameters      
LVEDd/height, mm/m (n=80) 27±3 28±3 0.24
LVESd/height, mm/m (n=79) 18±2 18±2 0.57
LV mass index, g/m2 (n=76) 45±9 38±10 0.020
Ejection fraction, % 59.7±4.0 60.4±5.0 0.54
LA volume index, ml/m2 (n=78) 22.9±5.3 22.1±5.2 0.61
E, cm/s 72±17 79±19 0.21
A, cm/s 70±20 80±19 0.095
E/A 1.2±1.1 1.0±0.3 0.49
Deceleration time, ms 209±34 216±38 0.52
e’ lateral, cm/s 11±4 11±3 0.30
E/e’ 6.6±1.9 8.0±2.9 0.022
Systolic PAP (n=36) 28±5 33±9 0.093
Global longitudinal strain, % (n=76) -20±2 -19±3 0.35
TAPSE (n=59) 21±4 22±4 0.57
Right ventricular S’ (n=70) 13±2 13±2 0.88
Follow-up Echocardiographic parameters      
LVEDd/height, mm/m (n=78) 28±3 27±2 0.49
LVESd/height, mm/m (n=78) 18±2 18±1 0.32
LV mass index, g/m2 (n=76) 46±8 41±8 0.04
Ejection fraction, % 59.0±4.0 59.5±3.8 0.67
LA volume index, ml/m2 (n=78) 23±6 25±6 0.40
E, cm/s 75±18 82±22 0.20
A, cm/s 74±18 89±27 0.015
E/A 1.01±0.3 0.96±0.29 0.28
Deceleration time, ms 197±35 233±56 0.04
e’ lateral, cm/s 12±3 9±1 0.001
E/e’ 6.9±2.1 9.5±3.6 0.001
Systolic PAP (n=43) 28±6 29±7 0.86
Global longitudinal strain, % (n=76) -19.9±1.9 -18.8±2.0 0.16
TAPSE (n=71) 22±4 21±4 0.73
Right ventricular S’ (n=71) 14±2 13±2 0.34
Ejection fraction drop ≥10% 2(3.0%) 1(7.1%) 0.45
Global longitudinal strain drop ≥-2% 2(3.0%) 1(7.1%) 0.45
Change in parameters: follow-baseline (Paired t-test P value)      
Change in global longitudinal strain -0.15%±2.7% (p=0.82) +0.53%±0.16%(p=0.61)  
Change in ejection fraction +0.69%±3.9% (p=0.16) -0.93%±5.2% (p=0.52)  
Change in E/e’ -0.32±2.1(p=0.22) +1.47±1.9 (p=0.014)  
Change in e’ -0.076±2.3(p=0.79) -1.6±2.2 (p=0.015)  
Table 5: Echocardiographic parameters stratified by worsening of diastolic function