Parameter
Sham
MI
WT
TRPV4
-/-
WT
TRPV4
-/-
EF (%)
59 ± 4
57 ± 4
27 ± 2
^
37 ± 4
*
#
LVEDV (ul)
60 ± 4
74 ± 7
110 ± 5
^
76 ± 11
#
LVESV (ul)
25 ± 4
32 ± 5
81 ± 5
^
51 ± 10
#
LVMI (mg/g)
2.8 ± 0.1
3.1 ± 0.4
3.7 ± 0.2
^
3.4 ± 0.2
Heart weight (HW; mg)
123 ± 4
138 ± 9
164 ± 7
^
152 ± 6
HW/Tibia ratio (mg/mm)
6.9 ± 0.3
7.7 ± 0.5
9.2 ± 0.3
^
8.7 ± 0.4
Lung weight (LW) wet (mg)
146 ± 2
144 ± 4
243 ± 24
^
224 ± 29
*
LW wet/Tibia ratio (mg/mm)
8.2 ± 0.2
8.0 ± 0.2
14 ± 1
^
13 ± 2
*
Body weight (gm)
27.2 ± 0.9
27.8 ± 0.8
22.6 ± 0.6
^
23.6 ± 0.8
*
Tibia length (mm)
17.8 ± 0.2
18.1 ± 0.2
17.8 ± 0.2
17.6 ± 0.1
Table 1:
WT and TRPV4-/- mouse parameters 1 week post sham or MIsurgery. Data are mean ± SEM. Unpaired t-tests with Welch’scorrections were performed,
#
p<0.05 vs. MI WT;
^
p<0.05 vs. Sham WT;
*
p<0.05 vs. Sham TRPV4
-/-
.
