Figure 1: Regression of Atherosclerosis. 1) Oxidation 2) Diapedesis 3) Foam Cell formation 4) RCT 5-6) Macrophage Egress from Lesion to Lumen and Adventitia, respectively. HDL can inhibit processes 1-3 (red arrows) and promote 4-6 (green arrows). Macrophage egress can occur through the up-regulation of CCR7 via activation of the SREBP (sterol-response element binding protein) pathway. Figure adapted from Feig JE et al. Macrophages, dendritic cells, and regression of atherosclerosis. Front Physiol. 2012 Jul 18; 3:286.