All patients NTP iNO SIL SIL/NO
Resp
(n = 20)
Nonresp
(n = 9)
Resp
(n = 19)
Nonresp
(n = 10)
Resp
(n = 18)
Nonresp
(n = 11)
Resp
(n = 19)
Nonresp
(n = 10)
mABP,
mmHg
92.26 ± 13.8 91.98 ± 13.34 92.97 ± 15.57 91.69 ± 12.56 93.44 ± 16.55 92.00 ± 13.99 92.73 ± 14.12 94.06 ± 14.66 88.93 ± 11.96
mPAP,
mmHg
42.49 ± 7.27 41.58 ± 8.30 44.40 ± 4.01 41.20 ± 8.02 44.84 ± 5.18 40.82 ± 8.38 45.13 ± 4.07 40.68 ± 7.83 45.82 ± 4.83
TPG,
mmHg
15.14 ± 4.32 13.55 ± 2.74 18.79 ± 5.05a 13.15 ± 2.50 19.04 ± 4.44a 13.43 ± 2.81 18.04 ± 4.88a 13.34 ± 2.78 18.67 ± 4.61b
CI l/
min/m2
1.87 ± 0.37 1.93 ± 0.32 1.77 ± 0.473 1.98 ± 0.30 1.76 ± 0.458 1.96 ± 0.33 1.77 ± 0.42 2.00 ± 0.29 1.72 ± 0.46
PAWP, /mmHg 27.24 ± 6.31 27.88 ± 7.88 25.61 ± 4.12 27.90 ± 7.69 25.80 ± 5.31 27.22 ± 7.97 27.09 ± 5.15 27.19 ± 7.69 27.15 ± 5.59
PVRI,
WU/m2
8.1 ± 3.31 7.03 ± 1.76 10.56 ± 4.51a 6.63 ± 1.52 10.97 ± 3.85b 6.86 ± 1.86 10.20 ± 4.05b 6.68 ± 1.58 10.88 ± 3.91b
SVRI,
WU/m2
41.6 ± 10.83 40.88 ± 9.39 43.68 ± 13.47 39.53 ± 8.81 45.91 ± 12.98 40.42 ± 10.11 44.02 ± 10.01 40.42 ± 9.21 44.24 ± 13.15
Data presented are mean ± standard deviation. Statistical analysis was performed Mann-Whitney U test. aP<0.05, bP<0.01 (non-responder vs. responder for respective study drug or combination thereof)
Table 3: Hemodynamic measurements obtained during right heart catheterization and vasoreactivity testing with studied drugs.