| |
NS-5 |
Resveratrol |
Quercetin |
d-Tocotrienol |
| ‡MicroRNAs |
Pre-dose |
Post-dose |
Post-dose |
Post-dose |
Post-dose |
| |
|
% |
% |
% |
% |
% |
| I |
Cardiovascular disease: |
| a |
Down-regulation |
| 1 |
miRNA-7a |
100 |
43 ± 1.02** |
74 ± 1.83** |
78 ± 1.76** |
61 ± 0.66** |
| 2 |
miRNA-10b |
100 |
34 ± 2.40** |
87 ± 0.64* |
91 ±1.13* |
42 ± 4.17** |
| 3 |
miRNA-15a |
100 |
68 ± 2.07** |
92 ± 1.89* |
67 ± 1.49** |
87 ± 0.24* |
| 4 |
miRNA-16 |
100 |
61 ± 1.66** |
87 ± 0.44* |
74 ± 1.16** |
71 ± 1.24** |
| 5 |
miRNA-20a |
100 |
61 ± 0.97** |
83 ± 0.75* |
93 ± 0.98* |
71 ± 1.07** |
| 6 |
miRNA-21 |
100 |
43 ± 2.14** |
79 ± 0.62** |
50 ± 1.50** |
40 ± 2.06** |
| 7 |
miRNA-29a |
100 |
83 ± 0.97* |
87 ± 2.32* |
74 ± 1.09** |
84 ± 0.41** |
| 8 |
miRNA-92a |
100 |
36 ± 2.25** |
79 ± 0.88** |
41 ± 1.68** |
55 ± 1.91** |
| 9 |
miRNA-126a |
100 |
71 ± 0.79** |
91 ± 1.45* |
67 ± 6.08** |
82 ± 0.52* |
| 10 |
miRNA-133a |
100 |
35 ± 1.52** |
84 ± 1.52* |
44 ± 2.44** |
72 ± 0.76** |
| 11 |
miRNA-200 |
100 |
64 ± 1.09** |
70 ± 2.22** |
79 ± 0.77** |
84 ± 0.69* |
| 12 |
miRNA-206 |
100 |
48 ± 0.98** |
58 ± 1.98** |
70 ± 1.41** |
78 ± 0.91** |
| b |
Up-regulation |
| 13 |
miRNA-499 |
100 |
127 ± 1.20** |
122 ± 0.57** |
144 ± 4.39** |
132 ± 2.00** |
| II |
Inflammation |
| c |
Up-regulation |
| 14 |
miRNA-373 |
100 |
176 ± 1.96** |
164 ± 4.20** |
136 ± 1.79** |
132 ± 1.30** |
| 15 |
miRNA-93 |
100 |
341 ± 3.38** |
331 ± 4.14** |
129 ± 2.50** |
310 ± 5.12** |
| 16 |
miRNA-192 |
100 |
362 ± 1.96** |
229 ± 7.91** |
357 ± 5.26** |
282 ± 1.98** |
| 17 |
miRNA-216a |
100 |
367 ± 5.89** |
220 ± 5.44** |
319 ± 6.81** |
177 ± 5.06** |
| 18 |
miRNA-503 |
100 |
259 ± 4.77** |
240 ± 4.93** |
121 ± 1.29** |
130 ± 3.11** |
| |
Down-regulation |
| d |
| 19 |
miRNA-101a |
100 |
55 ± 1.20** |
63 ± 2.18** |
84 ± 1.06* |
66 ± 1.37** |
| 20 |
miRNA-125a |
100 |
64 ± 1.85** |
68 ± 1.22** |
87 ± 0.79* |
86 ± 1.60* |
| 21 |
miRNA-155 |
100 |
23 ± 2.53** |
66 ± 4.81** |
57 ± 0.63** |
26 ± 2.05** |
| 22 |
miRNA-223 |
100 |
62 ± 2.36** |
40 ± 5.06** |
46 ± 1.44** |
82 ± 1.81* |
| III |
Aging |
| e |
Down-regulation |
| 23 |
miRNA-146a |
100 |
21 ± 1.98** |
44 ± 4.48** |
33 ± 3.31** |
26 ± 1.93** |
* - **Values in a row sharing a common asterisk are significantly different at *P<0.01; **P<0.001.
‡The Effects of δ-tocotrienol on miRNAs-7a, miR-15a, miR-20a, miR-21, miR-29a, miR-92a, miR-200, miR-206 (in BJMMR. 2015; 6(4): 351-366), and miR-16-1, miR-125,
miR-133a, miR-155, miR-223, miR-372, miR-10b, miR-18a, miR-214 (in JCEC. 2015; in press) have been reported. These miRNAs of δ-tocotrienol were included for
comparison purpose only. |
