Pharmacokinetic

A. Subjects # 1 - 11 (125 mg)
	δ-Tocotrienol				γ-Tocotrienol
A:	125 mg	250 mg	500 mg	B:	125 mg	250 mg	500 mg
1.Area Under Curve-0 -10(AUC_0-10;ng/ml)	2463.91 ± 191.62^a*	5412.50 ± 274.04^b	14985.73 ± 362.63^c		1258.18 ± 126.26^a*	5412.50 ± 274.04^b	6895.96 ± 159.49^c
2.Area Under Curve-0-∞(AUC_0-∞;ng/ml)	2586.41 ± 201.01^a*	5514.75 ± 287.01^b	17111.94 ± 444.71^c		1647.95 ± 270.72^a*	5514.75 ± 287.01^b	7818.82 ± 397.38^c
3.Plasma Peak Concentration (C_max;ng/ml)	828.82 ± 24.28^a	1920.36 ± 57.99^b	3278.00 ± 124.13^c		281.34 ± 21.22^a	833.73.36 ± 28.22^b	1224.64 ± 61.28^c
4.Time to achieve plasma peak (T_max;h)	3.00	3.00	4.00		3.00	3.00	3.55 ± 0.52
5. Elimination of Half-lifetime(t_1/2;h)	1.74 ± 0.36^a	1.39 ± 0.22^a	2.54 ± 0.05^b		3.82 ± 0.99^a	1.39 ± 0.28^b	2.25 ± 0.32^c
6. Time of clearance(Cl-T;I/h)	0.049 ± 0.004^a	0.045 ± 0.002^a	0.030 ± 0.001^b		0.078 ± 0.012^a	0.045 ± 0.002^a	0.061 ± 0.010^b
7. Apparent volume of distribution(Vd/f)	0.179 ± 0.035^a	0.114 ± 0.011^b	0.613 ± 0.102^c		0.553 ± 0.084^a	0.461 ± 0.114^a	0.635 ± 0.060^b
8. Elimination rate constant (ke;h^-1)	0.381 ± 0.059^a	0.401 ± 0.039^b	0.050 ± 0.008^c		0.113 ± 0.026^a	0.133 ± 0.037^a	0.097 ± 0.021^b
β-Tocotrienol α-Tocotrienol
C:	125 mg	250 mg	500 mg	D:	125 mg	250 mg	500 mg
1.Area Under Curve-0 -10(AUC_0-10;ng/ml)	6933.73 ± 129.58^a*	7080.36 ± 206.62^a	7680.41 ± 272.59^b		869.96 ± 43.95^a*	1369.91 ± 26.30^b	1900.68 ± 46.29^c
2.Area Under Curve-0-∞(AUC_0-∞;ng/ml)	8839.28 ± 656.29^a*	9184.14 ± 674.76^a	10391.37 ± 621.69^b		1041.77 ± 108.82^a*	1558.09 ± 77.13^b	22290.14 ± 65.53^c
3.Plasma Peak Concentration (C_max;ng/ml)	979.00 ± 79.45^a	1083.73 ± 82.26^b	1279.00 ± 116.44^c		139.91 ± 11.03^a	204.91 ± 9.47^b	290.09 ± 9.84^c
4.Time to achieve plasma peak (T_max;h)	4.00	3.64. ± 0.41	3.00		2.73 ± 0.65	3.00	3.00
5. Elimination of Half-lifetime (t_1/2;h)	3.92 ± 0.86^a	3.90 ± 0.79^a	4.39 ± 0.63^a		2.62 ± 0.81^a	2.89 ± 0.84^a	3.71 ± 0.29^b
6. Time of clearance(Cl-T;I/h)	0.094 ± 0.007^a	0.090 ± 0.007^a	0.080 ± 0.005^b		0.303 ± 0.135^a	0.161 ± 0.008^b	0.109 ± 0.003^c
7. Apparent volume of distribution(Vd/f)	0.174 ± 0.011^a	0.223 ± 0.013^b	0.415 ± 0.019^c		0.590 ± 0.061^a	0.922 ± 0.067^b	1.365 ± 0.045^c
8. Elimination rate constant (ke;h^-1)	0.542 ± 0.062^a	0.404 ± 0.032^b	0.192 ± 0.014^c		1.234 ± 0.211^a	0.201 ± 0.050^b	0.214 ± 0.009^b

Table 3: Pharmacokinetic parameters after feeding single dose of various concentrations of δ-tocotrienol (125, or 250, or 500 mg) in one day.
^a-cValues in a row not sharing a common letter are significantly different at P<0.001 - 0.01.