Pharmacokinetic

	d-Tocopherol				g-Tocopherol
A:	125 mg	250 mg	500 mg	B:	125 mg	250 mg	500 mg

1. Area Under Curve-0 - 10 (AUC_0-10; ng/ml)	1971.00 ± 197.23^a*	5007.05 ± 164.16^b	5119.68 ± 268.21^b		3564.64 ± 136.64^a*	3575.96 ± 154.98^a	3898.41 ± 130.37^b
2. Area Under Curve-0 - ∞ (AUC_0-∞; ng/ml)	2647.23 ± 243.57^a*	7726.83 ± 484.561^b	6373.12 ± 633.37^c		4117.63 ± 205.74^a*	4912.99 ± 374.53^b	5638.22 ± 616.15^c
3. Plasma Peak Concentration (C_max; ng/ml)	341.18 ± 62.19^a	756.27 ± 72.70^b	1027.73 ± 71.93^c		507.64 ± 24.68^a	643.36 ± 37.26^b	605.64 ± 48.17^b
4. Time to achieve plasma peak (T_max; h)	6.00	4.18 ± 0.60	3.00		5.46 ± 0.93	3.00	2.82 ± 0.41
5. Elimination of Half-life time (t_1/2; h)	3.25 ± 0.79^a	5.22 ± 0.62^b	3.58 ± 0.67^a		2.45 ± 0.37^a	5.17 ± 1.06^b	4.99 ± 0.88^b
6. Time of clearance (Cl-T; I/h)	0.048 ± 0.004^a	0.032 ± 0.002^b	0.079 ± 0.007^c		0.038 ± 0.026^a	0.051 ± 0.004^b	0.086 ± 0.018^c
7. Apparent volume of distribution (Vd/f)	0.688 ± 0.133^a	0.431 ± 0.050^b	0.436 ± 0.036^b		0.209 ± 0.021^a	0.350 ± 0.020^b	0.683 ± 0.041^c
8. Elimination rate constant (ke; h^-1)	0.118 ± 0.032^a	0.076 ± 0.008^b	0.183 ± 0.027^c		0.184 ± 0.121^a	0.146 ± 0.013^b	0.126 ± 0.026^a

b-Tocopherol a-Tocopherol
C:	125 mg	250 mg	500 mg	D:	125 mg	250 mg	500 mg

1. Area Under Curve-0 - 10 (AUC_0-10; ng/ml)	6410.18 ± 195.55^a*	5973.77 ± 403.98^a	6182.55 ± 195.67^a		14754.27 ± 218.40.21^a*	15852.50 ± 518.04^a	18681.86 ± 600.04^b
2. Area Under Curve-0 - ∞ (AUC_0-∞; ng/ml)	6937.76 ± 198.62^a*	7550.96 ± 495.54^ab	7633.65 ± 393.05^b		22288.86 ± 1504.88.69^a*	23622.40 ± 2044.09^ab	26547.56 ± 1429.60^b
3. Plasma Peak Concentration (C_max; ng/ml)	956.09 ± 70.06^a	949.91 ± 126.37^a	1045.09 ± 147.81^a		1822.00 ± 48.24^a	1931.00 ± 92.54^b	2188 ± 147.61^c
4. Time to achieve plasma peak (T_max; h)	5.18 ± 1.17	3.09 ± 0.30	3.09 ± 0.32		6.00	6.00	5.46 ± 0.93
5. Elimination of Half-life time (t_1/2; h)	1.82 ± 0.23	3.97 ± 0.66^a	3.27 ± 0.61^a		4.99 ± 069^a	4.91 ± 0.84^a	3.58 ± 0.67^a
6. Time of clearance (Cl-T; I/h)	0.119 ± 0.003^a	0.110 ± 0.007^b	0.112 ± 0.006^b		0.017 ± 0.015^a	0.011 ± 0.001^b	0.019 ± 0.001^a
7. Apparent volume of distribution (Vd/f)	0.096 ± 0.006^a	0.227 ± 0.026^b	0.410 ± 0.035^c		0.070 ± 0.002^a	0.127 ± 0.004^b	0.232 ± 0.010^c
8. Elimination rate constant (Ke; h^-1)	1.247 ± 0.073^a	0.489 ± 0.063^b	0.275 ± 0.023^c		0.237 ± 0.217^a	0.084 ± 0.008^ab	0.081 ± 0.006^b

Table 4: Pharmacokinetic parameters after feeding single dose of various concentrations of δ-tocotrienol (125, or 250, or 500 mg) in one day.
^a-cValues in a row not sharing a common letter are significantly different at P<0.001 - 0.01.
*Values represent Standard Deviation (SD).