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Figure 3: Plasma peak concentrations (Cmax, ng/ml) of δ-, γ-, β-, α-tocopherols of various doses: The doses of 750 mg or 1000 mg/d of DeltaGold-based δ-tocotrienol were administered to healthy fed subjects. The plasma samples were collected at different time points from each subject, and processed to carry out normal phase HPLC analyses as described in Materials and Methods section. 3A: The plasma concentration of δ- tocopherol at 0 h, 1 h, 2 h, 4 h, 6 h, and 8 h time points. 3B: The plasma concentration of γ-tocopherol at 0–8 h time points. 3C: The plasma concentration of β-tocopherol at 0–8 h time points. 3D: The plasma concentration of α-tocopherol at 0–8 h time points. Values are means ± standard deviation (n=3/dose). Values are significantly different compared to 750 mg dose versus 1000 mg dose at *P<0.05; or **P <0.01 from each other. |