A: |
δ -Tocotrienol |
γ- Tocotrienol |
β -Tocotrienol |
α - Tocotrienol |
1. Area Under the Curve-t0- t8 (AUCt0- 8; ng/ml) |
6620.87 ± 49.67 a* |
6961.92 ± 97.55b |
11473.96 ± 316.15c |
197.89 ± 1.02d* |
2. Area Under the Curve-t0- (AUCt0- ∞ ng/ml) |
8687.69 ± 201.01a* |
7895.14 ± 73.43b |
11709.23 ± 459.66c |
225.50 ± 6.79d* |
3. Cumulative Area Under the Curve-t0-∞ (AUMCt0- ∞ ng/ml) |
52496.47 ± 2095.81a |
32479.70 ± 606.11b |
43200.35 ± 3122.43c |
1009.47 ± 88.31d |
4. Mean Residence Time (/h) |
6.04 ± 0.139a |
4.11 ± 0.049b |
3.69 ± 0.16b |
4.47 ± 0.26b |
5. Peak Plasma Concentration (Cmax; ng/ml) |
1444.23 ± 53.07a |
1352.41 ± 28.14b |
1885.20 ± 90.95c |
30.25 ± 1.06d |
6. Time to achieve plasma peak (Tmax; h) |
4.00a |
4.00b |
4.00c |
3.33 + 1.16a |
7. Elimination of Half-life time (t1/2; h) |
2.74 ± 0.13a |
1.96 ± 0.06b |
1.02 ± 0.34c |
2.21 ± 0.18a |
8. Time of clearance (Cl-T; I/h) |
0.086 ± 0.002a |
0.095 ± 0.001a |
0.064 ± 0.003b |
3.33 ± 0.102c |
9. Apparent volume of distribution (Vd/f; ml) |
0.341 ± 0.012a |
0.269 ± 0.008b |
0.094 ± 0.029c |
10.583 ± 0.543d |
10. Elimination rate constant (ke; h-1) |
0.253 ± 0.167a |
0.353 ± 0.125a |
0.681 ± 0.103b |
0.315 ± 0.188a |
B: |
δ -Tocopherol |
γ-Tocopherol |
β -Tocopherol |
α-Tocopherol |
1. Area Under the Curve-t0- t8 (AUCt0- 8; ng/ml) |
7766.79 ± 192.42a* |
3066.14 ± 187.49b |
4623.38 ± 81.72c |
18282.03 ± 275.20d* |
2. Area Under the Curve-t0-∞(AUCt0- ∞ ng/ml) |
9294.91 ± 232.20 a* |
3960.39 ± 251.48b |
5831.54 ± 141.01c |
|
3. Cumulative Area Under the Curve-t0-∞ (AUMCt0-∞ |
45136.59 ± 3348.58a |
22002.09 ± 2112.78b |
32588.53 ± 2555.89c |
|
4. Mean Residence Time (/h) |
4.85 ± 0.269a |
5.55 ± 0.244b |
5.58 ± 0.314b |
|
5. Peak Plasma Concentration (Cmax; ng/ml) |
1353.79 ± 79.45a |
547.45 ± 11.77b |
704.16 ± 28.18c |
2754.36 ± 83.72d |
6. Time to achieve plasma peak (Tmax; h) |
3.33 ± 1.16a |
4.00b |
4.00a |
6.00b |
7. Elimination of Half-life time (t1/2; h) |
2.44 ± 0.19a |
2.92 ± 0.21b |
3.02 ± 0.32b |
|
8. Time of clearance (Cl-T; I/h) |
0.081 ± 0.002a |
0.190 ± 0.012b |
0.129 ± 0.003c |
|
9. Apparent volume of distribution (Vd/f; ml) |
0.284 ± 0.021a |
0.799 ± 0.047b |
0.556 ± 0.046c |
|
10. Elimination rate constant (ke; h-1) |
0.286 ± 0.095a |
0.238 ± 0.255b |
0.232 ± 0.065b |
|