tocotrienol

A:	δ -Tocotrienol	γ- Tocotrienol	β -Tocotrienol	α - Tocotrienol
1. Area Under the Curve-t₀- t₈ (AUCt_{0- 8}; ng/ml)	6620.87 ± 49.67 ^a*	6961.92 ± 97.55^b	11473.96 ± 316.15^c	197.89 ± 1.02^d*
2. Area Under the Curve-t₀- (AUCt_{0- ∞} ng/ml)	8687.69 ± 201.01^a*	7895.14 ± 73.43^b	11709.23 ± 459.66^c	225.50 ± 6.79^d*
3. Cumulative Area Under the Curve-t_0-∞ (AUMCt_{0- ∞} ng/ml)	52496.47 ± 2095.81^a	32479.70 ± 606.11^b	43200.35 ± 3122.43^c	1009.47 ± 88.31^d
4. Mean Residence Time (/h)	6.04 ± 0.139^a	4.11 ± 0.049^b	3.69 ± 0.16^b	4.47 ± 0.26^b
5. Peak Plasma Concentration (C_max; ng/ml)	1444.23 ± 53.07^a	1352.41 ± 28.14^b	1885.20 ± 90.95^c	30.25 ± 1.06^d
6. Time to achieve plasma peak (T_max; h)	4.00^a	4.00^b	4.00^c	3.33 + 1.16^a
7. Elimination of Half-life time (t_1/2; h)	2.74 ± 0.13^a	1.96 ± 0.06^b	1.02 ± 0.34^c	2.21 ± 0.18^a
8. Time of clearance (Cl-T; I/h)	0.086 ± 0.002^a	0.095 ± 0.001^a	0.064 ± 0.003^b	3.33 ± 0.102^c
9. Apparent volume of distribution (Vd/f; ml)	0.341 ± 0.012^a	0.269 ± 0.008^b	0.094 ± 0.029^c	10.583 ± 0.543^d
10. Elimination rate constant (ke; h^-1)	0.253 ± 0.167^a	0.353 ± 0.125^a	0.681 ± 0.103^b	0.315 ± 0.188^a
B:	δ -Tocopherol	γ-Tocopherol	β -Tocopherol	α-Tocopherol
1. Area Under the Curve-t₀- t₈ (AUCt_{0- 8}; ng/ml)	7766.79 ± 192.42^a*	3066.14 ± 187.49^b	4623.38 ± 81.72^c	18282.03 ± 275.20^d*
2. Area Under the Curve-t_0-∞(AUCt_{0- ∞} ng/ml)	9294.91 ± 232.20 ^a*	3960.39 ± 251.48^b	5831.54 ± 141.01^c
3. Cumulative Area Under the Curve-t_0-∞ (AUMCt_0-∞	45136.59 ± 3348.58^a	22002.09 ± 2112.78^b	32588.53 ± 2555.89^c
4. Mean Residence Time (/h)	4.85 ± 0.269^a	5.55 ± 0.244^b	5.58 ± 0.314^b
5. Peak Plasma Concentration (C_max; ng/ml)	1353.79 ± 79.45^a	547.45 ± 11.77^b	704.16 ± 28.18^c	2754.36 ± 83.72^d
6. Time to achieve plasma peak (T_max; h)	3.33 ± 1.16^a	4.00^b	4.00^a	6.00^b
7. Elimination of Half-life time (t_1/2; h)	2.44 ± 0.19^a	2.92 ± 0.21^b	3.02 ± 0.32^b
8. Time of clearance (Cl-T; I/h)	0.081 ± 0.002^a	0.190 ± 0.012^b	0.129 ± 0.003^c
9. Apparent volume of distribution (Vd/f; ml)	0.284 ± 0.021^a	0.799 ± 0.047^b	0.556 ± 0.046^c
10. Elimination rate constant (ke; h^-1)	0.286 ± 0.095^a	0.238 ± 0.255^b	0.232 ± 0.065^b

^a-dValues in a row not sharing a common letter are significantly different at P <0.05 - 0.01. *Values represent Standard Deviation (SD).

Table 4: Pharmacokinetic parameters after feeding single dose of 750 mg of δ-tocotrienol in one day.