feeding

A:	δ –Tocotrienol	γ –Tocotrienol	β –Tocotrienol	α –Tocotrienol
1. Area Under the Curve-t₀-t₈ (AUCt_0-8; ng/ml)	7450.10 ± 89.01^a*	7479.89 ±129.37^a	11895.22 ± 231.01^b	547.58 ±19.06^c*
2. Area Under the Curve-t_0-∞ (AUCt_{0- ∞} ng/ml)	9633.18 ± 382.98^a*	8626.41 ± 277.17^b	13475.36 ± 258,61^c	646.41 ± 25.09^d*
3. Cumulative Area Under the Curve-t_0-∞ (AUMCt_{0- ∞} ng/ml)	57198.99 ± 5006.46^a	37413.68 ± 2525.63^a	59888.88 ± 1767.19^a	3059/45 ± 178.82^c
4. Mean Residence Time (/h)	5.93 ± 0.364^a	4.33 ± 0.159^b	4.44 ± 0.076^b	4.73 ± 0.123^b
5. Peak Plasma Concentration (C_max; ng/ml)	1591.89 ± 43.97^a	1386.99.41 ± 12.49^b	1948.13 ± 66.43^c	115.84 ± 3.57^d
6. Time to achieve plasma peak (T_max; h)	4.00^a	4.00^a	3.33 ± 1.16^a	4.00^a
7. Elimination of Half-life time (t_1/2; h)	2.68 ± 0.29^a	2.12 ± 0.14^b	2.11 ± 0.03^b	2.15 ± 0.13^b
8. Time of clearance (Cl-T; I/h)	0.078 ± 0.003^a	0.116 ± 0.004^b	0.074 ± 0.001^a	3.33 ± 0.102^c
9. Apparent volume of distribution (Vd/f; ml)	0.300 ± 0.021^a	0.354 ± 0.014^b	0.226 ± 0.006^c	4.797 ± 0.232^d
10. Elimination rate constant (ke; h^-1)	0.260 ± 0.143^a	0.328 ± 0.286^a	0.327 ± 0.167^a	0.694 ± 0.443^a
B:	δ –Tocopherol	γ –Tocopherol	β –Tocopherol	α –Tocopherol
1. Area Under the Curve-t₀-t₈ (AUCt_0-8; ng/ml)	8305.81 ± 216.66^a*	3107.38 ± 147.51^b	7220.65 ± 183.49^c	18531.38 ± 96.78^d*
2. Area Under the Curve-t_0-∞ (AUCt_{0- ∞} ng/ml)	10169.12 ± 68.88^a*	3739.17 ± 191.92^b	9417.46 ± 531.19^b
3. Cumulative Area Under the Curve-t_0-∞ (AUMCt_{0- ∞} ng/ml)	51639.53 ± 2781.56^a	18102.24 ± 1302.29^b	54126.15 ± 5920.86^a
4. Mean Residence Time (/h)	5.08 ± 0.251^a	4.84 ± 0.145^a	5.74 ± 0.310^b
5. Peak Plasma Concentration (C_max; ng/ml)	1472.84 ± 71.21^a	589.38 ± 39.07^b	1325.03 ± 55.60^a	2914.95 ± 39.04^c
6. Time to achieve plasma peak (T_max; h)	4.00^a	4.00^a	4.00^a	6.00^b
7. Elimination of Half-life time (t_1/2; h)	2.58 ± 0.22^ab	2.38 ± 0.19^a	2.94 ± 0.19^b
8. Time of clearance (Cl-T; I/h)	0.098 ± 0.001^a	0.190 ± 0.012^a	0.129 ± 0.003^b
9. Apparent volume of distribution (Vd/f; ml)	0.366 ± 0.030^a	0.920 ± 0.070^b	0.450 ± 0.004^c
10. Elimination rate constant (ke; h^-1)	0.268 ± 0.033^a	0.207 ± 0.171^b	0.287 ± 0.750^c

^a-dValues in a row not sharing a common letter are significantly different at P<0.01-0.001.
*Values represent Standard Deviation (SD).

Table 5: Pharmacokinetic parameters after feeding single dose of 1000 mg of δ -tocotrienol in one day.